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PTGR2-IN-22
CAS No. 349093-44-3
PTGR2-IN-22( —— )
Catalog No. M22891 CAS No. 349093-44-3
PTGR2-IN-22 is a potent inhibito of PTGR2r(IC50 : 0.7 μM). It increases 15-keto-PGE2-dependent PPARγ transcriptional activity in PTGR2-transfected HEK293T cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 71 | In Stock |
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| 5MG | 65 | In Stock |
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| 10MG | 98 | In Stock |
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| 25MG | 181 | In Stock |
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| 50MG | 262 | In Stock |
|
| 100MG | 373 | In Stock |
|
| 200MG | 507 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePTGR2-IN-22
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NoteResearch use only, not for human use.
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Brief DescriptionPTGR2-IN-22 is a potent inhibito of PTGR2r(IC50 : 0.7 μM). It increases 15-keto-PGE2-dependent PPARγ transcriptional activity in PTGR2-transfected HEK293T cells.
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DescriptionPTGR2-IN-22 is a potent inhibito of PTGR2r(IC50 : 0.7 μM). It increases 15-keto-PGE2-dependent PPARγ transcriptional activity in PTGR2-transfected HEK293T cells.
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In VitroA screen of structural analogs of 20 identified PTGR2-IN-1, which shows substantially increased potency (>20-fold) in assays measuring either competition of 8-labeling or 15-keto-PGE2 reductase activity (IC50 = 0.6 μM) of recombinant PTGR2, as well as an inactive control compound 23. PTGR2-IN-1 (Compound 22) blocks FFF 8 labeling of endogenous PTGR2 in HEK293T cells with good potency (complete inhibition at 5 μM and ~80% inhibition at 500 nM) and excellent selectivity.
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorPTGR2
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Research Area——
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Indication——
Chemical Information
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CAS Number349093-44-3
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Formula Weight310.39
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Molecular FormulaC19H22N2O2
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Purity>98% (HPLC)
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SolubilityDMSO:100 mg/mL (322.18 mM; Need ultrasonic)
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SMILESCOC1=CC=CC=C1N2CCN(C(CC3=CC=CC=C3)=O)CC2
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Parker CG, et al. Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017;168(3):527-541.e29.
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