Cart
sales@molnova.com
Home - Products - Metabolic Enzyme/Protease - Dehydrogenase - PfDHODH-IN-2

PfDHODH-IN-2

CAS No. 425629-94-3

PfDHODH-IN-2( —— )

Catalog No. M22750 CAS No. 425629-94-3

PfDHODH-IN-2 is a dihydrothiophenone derivative, is a potent Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH, IC50 : 1.11 μM) inhibitor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 102 In Stock
5MG 93 In Stock
10MG 141 In Stock
25MG 259 In Stock
50MG 375 In Stock
100MG 533 In Stock
200MG 724 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    PfDHODH-IN-2
  • Note
    Research use only, not for human use.
  • Brief Description
    PfDHODH-IN-2 is a dihydrothiophenone derivative, is a potent Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH, IC50 : 1.11 μM) inhibitor.
  • Description
    PfDHODH-IN-2 is a dihydrothiophenone derivative, is a potent Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH, IC50 : 1.11 μM) inhibitor . It is used an antimalarial agent and can be used for the research of malaria.
  • In Vitro
    Malaria is a global parasitic infectious disease caused by Plasmodium parasites, among which Plasmodium falciparum is the most dangerous one with the highest rates of complications and mortality.PfDHODH-IN-2 shows an overall selectivity for PfDHODH (IC50=1.113 μM) over hDHODH (IC50>50 μM). PfDHODH-IN-2 demonstrats in vitro potency against the 3D7 and Dd2 strains of P. falciparum with IC50 values of both >20 μM, respectively in whole cell assays.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    Dehydrogenase
  • Recptor
    PfDHODH
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    425629-94-3
  • Formula Weight
    297.76
  • Molecular Formula
    C13H12ClNO3S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:12 mg/mL?(40.3 mM;?Need ultrasonic)
  • SMILES
    CCOC(=O)C1=C(Nc2ccc(Cl)cc2)SCC1=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Minghao Xu, et al. Novel selective and potent inhibitors of malaria parasite dihydroorotate dehydrogenase: discovery and optimization of dihydrothiophenone derivatives. J Med Chem. 2013 Oct 24;56(20):7911-24.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • IDH889

    IDH889 is a brain penetrant, an allosteric and mutant specific IDH1 inhibitor. IDH889 has effective selectivity for IDH1 R132* mutations (IC50s: 0.02 μM, 0.072 μM, and 1.38 μM for IDH1R132H, IDH1R132C, and IDH1wt).

  • GSK864

    GSK864 is an IDH1 mutant inhibitor that inhibits IDH1 mutants R132C, R132H, and R132G, and is used in the study of cardiovascular and oncology diseases.

  • AGI-6780

    AGI-6780 is a potent and selective inhibitor of IDH2 R140Q mutant with IC50 of 23 nM.

Sign In Join Free