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MitoBloCK-10
CAS No. 394694-98-5
MitoBloCK-10( 3-fluoro-N'-[(E)-(5-nitrothiophen-2-yl)m )
Catalog No. M22749 CAS No. 394694-98-5
MitoBloCK-10 inhibits Tim44 binding to the precursor and to Hsp70.MitoBloCK-10 is the first small molecule modulator to attenuate protein-associated motor (PAM) complex activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 139 | In Stock |
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| 5MG | 147 | In Stock |
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| 10MG | 217 | In Stock |
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| 25MG | 369 | In Stock |
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| 50MG | 517 | In Stock |
|
| 100MG | 724 | In Stock |
|
| 200MG | 986 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameMitoBloCK-10
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NoteResearch use only, not for human use.
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Brief DescriptionMitoBloCK-10 inhibits Tim44 binding to the precursor and to Hsp70.MitoBloCK-10 is the first small molecule modulator to attenuate protein-associated motor (PAM) complex activity.
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DescriptionMitoBloCK-10 inhibits Tim44 binding to the precursor and to Hsp70.MitoBloCK-10 is the first small molecule modulator to attenuate protein-associated motor (PAM) complex activity.
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In VitroCell Viability Assay Cell Line:A plasmid expressing Su9-Ura3-myc was integrated at the LEU2 locus in WT and tim23-2 strains.Concentration:100 μM.Incubation Time:30 min.Result:WT strain expressing Su9-Ura3 failed to grow, whereas the tim23-2 mutant expressing Su9-Ura3 grew much faster. The strains grew at a similar rate when the medium was supplemented with uracil.Cell Viability Assay Cell Line:HeLa cells.Concentration:0-100 μM.Incubation Time:24 h.Result:Inhibited HeLa cells vibility, with an IC50 of 17.2 μM.
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In Vivo——
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Synonyms3-fluoro-N'-[(E)-(5-nitrothiophen-2-yl)m
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research Area——
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Indication——
Chemical Information
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CAS Number394694-98-5
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Formula Weight293.28
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Molecular FormulaC12H8FN3O3S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (426.23 mM)
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SMILES[O-][N+](=O)c1ccc(\C=N\NC(=O)c2cccc(F)c2)s1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Non Miyata, et al. Adaptation of a Genetic Screen Reveals an Inhibitor for Mitochondrial Protein Import Component Tim44. J Biol Chem. 2017 Mar 31;292(13):5429-5442.
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