MF-438( —— )

Catalog No. M22502 CAS No. 921605-87-0

MF-438 is an effective and orally bioavailable stearoyl-CoA desaturase 1 (SCD1) inhibitor (EC50: 2.3 nM for rSCD1). In a mouse model, MF-438 shows an ED50 between 1 and 3 mg/kg.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	236	In Stock
2MG	140	In Stock
5MG	215	In Stock
10MG	328	In Stock
25MG	557	In Stock
50MG	779	In Stock
100MG	1079	In Stock
200MG	Get Quote	In Stock
500MG	2158	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

MF-438
Note

Research use only, not for human use.
Brief Description

MF-438 is an effective and orally bioavailable stearoyl-CoA desaturase 1 (SCD1) inhibitor (EC50: 2.3 nM for rSCD1). In a mouse model, MF-438 shows an ED50 between 1 and 3 mg/kg.
Description

MF-438 is an effective and orally bioavailable stearoyl-CoA desaturase 1 (SCD1) inhibitor (EC50: 2.3 nM for rSCD1). In a mouse model, MF-438 shows an ED50 between 1 and 3 mg/kg.
In Vitro

——
In Vivo

MF-438 exhibits an ED50 between 1 and 3 mg/kg in a mouse model.
Synonyms

——
Pathway

Metabolic Enzyme/Protease
Target

Dehydrogenase
Recptor

SCD
Research Area

——
Indication

——

Chemical Information

CAS Number

921605-87-0
Formula Weight

421.44
Molecular Formula

C19H18F3N5OS
Purity

>98% (HPLC)
Solubility

DMSO:62.5 mg/mL (148.30 mM; Need ultrasonic)
SMILES

Cc1nnc(s1)-c1ccc(nn1)N1CCC(CC1)Oc1ccccc1C(F)(F)F
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Léger S, et al. Synthesis and biological activity of a potent and orally bioavailable SCD inhibitor (MF-438). Bioorg Med Chem Lett. 2010 Jan 15;20(2):499-502.

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