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VU591
CAS No. 1222810-74-3
VU591( —— )
Catalog No. M22472 CAS No. 1222810-74-3
VU591 is the first reported selective, small-molecule ROMK inhibitor(IC50 of 0.24 μM). It inhibits potassium transport in isolated perfused rat collecting duct tubules with no effect on sodium transport.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 45 | In Stock |
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| 5MG | 41 | In Stock |
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| 10MG | 69 | In Stock |
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| 25MG | 136 | In Stock |
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| 50MG | 238 | In Stock |
|
| 100MG | 356 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 764 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameVU591
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NoteResearch use only, not for human use.
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Brief DescriptionVU591 is the first reported selective, small-molecule ROMK inhibitor(IC50 of 0.24 μM). It inhibits potassium transport in isolated perfused rat collecting duct tubules with no effect on sodium transport.
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DescriptionVU591 is the first reported selective, small-molecule ROMK inhibitor(IC50 of 0.24 μM). It inhibits potassium transport in isolated perfused rat collecting duct tubules with no effect on sodium transport.
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In VitroVU591 is a selective ROMK inhibitor and a ROMK channel pore blocker. VU591 can bind serum protein and has high metabolic stability.
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In VivoVU591 (i.c.v.; 1.842 μg) significantly decreases the immobile time in TST. Animal Model:Male ICR miceDosage:1.842 μg Administration:i.c.v.; 1.842 μg; Result:Showed antidepressive effect in the tail suspension test (TST).
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetPotassium Channel
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RecptorKir1.1|ROMK
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Research Area——
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Indication——
Chemical Information
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CAS Number1222810-74-3
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Formula Weight368.3
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Molecular FormulaC16H12N6O5
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Purity>98% (HPLC)
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SolubilityDMSO:60 mg/mL (162.91 mM; Need ultrasonic)
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SMILES[O-][N+](=O)c1ccc2nc(COCc3nc4ccc(cc4[nH]3)[N+]([O-])=O)[nH]c2c1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Bhave G, et al. Development of a selective small-molecule inhibitor of Kir1.1, the renal outer medullary potassium channel. Mol Pharmacol. 2011 Jan;79(1):42-50.
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