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CCI-006
CAS No. 292053-42-0
CCI-006( —— )
Catalog No. M22449 CAS No. 292053-42-0
CCI-006 is a selective inhibitor and chemosensitizer of MLL-rearranged leukemia cells. It inhibits mitochondrial respiration resulting in insurmountable mitochondrial depolarization and a pro-apoptotic unfolded protein response in a subset of MLL-r leukemia cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 86 | In Stock |
|
| 5MG | 79 | In Stock |
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| 10MG | 126 | In Stock |
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| 25MG | 219 | In Stock |
|
| 50MG | 310 | In Stock |
|
| 100MG | 463 | In Stock |
|
| 200MG | 626 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameCCI-006
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NoteResearch use only, not for human use.
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Brief DescriptionCCI-006 is a selective inhibitor and chemosensitizer of MLL-rearranged leukemia cells. It inhibits mitochondrial respiration resulting in insurmountable mitochondrial depolarization and a pro-apoptotic unfolded protein response in a subset of MLL-r leukemia cells.
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DescriptionCCI-006 is a selective inhibitor and chemosensitizer of MLL-rearranged leukemia cells. It inhibits mitochondrial respiration resulting in insurmountable mitochondrial depolarization and a pro-apoptotic unfolded protein response in a subset of MLL-r leukemia cells.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorMitochondria
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Research Area——
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Indication——
Chemical Information
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CAS Number292053-42-0
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Formula Weight332.33
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Molecular FormulaC15H12N2O5S
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Purity>98% (HPLC)
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SolubilityDMSO:83.33 mg/mL (250.74 mM)
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SMILESCOC(=O)C(\C#N)=C\c1ccc(o1)-c1ccc(cc1)S(N)(=O)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Somers K, et al. A novel small molecule that kills a subset of MLL-rearranged leukemia cells by inducing mitochondrial dysfunction. Oncogene. 2019 Jan 22.
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