TRIM

Research use only, not for human use.

TRIM is an inhibitor of nNOS.TRIM is a poor inhibitor of bovine aortic endothelial NOS with an IC50 of 1057.5 microM.

TRIM is an inhibitor of nNOS.TRIM is a poor inhibitor of bovine aortic endothelial NOS with an IC50 of 1057.5 microM. TRIM (10-50 mg kg-1) administered i.p. exhibits dose-related antinociceptive activity in the mouse (assessed as inhibition of late phase formalin-induced hindpaw licking behaviour) with an ED50 of 85.8 mumol kg-1. In contrast, TRIM (50 mg kg-1, i.p.) failed to influence mean arterial blood pressure in the urethane-anaesthetized mouse.

TRIM is a relatively weak inhibitor of eNOS (IC50, 1057.5 μM).

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1-(2-Trifluoromethylphenyl)imidazole

Immunology/Inflammation

NOS

nNOS

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——

25371-96-4

212.17

C10H7F3N2

>98% (HPLC)

In Vitro:?DMSO : 250 mg/mL (1178.30 mM)

FC(F)(F)c1ccccc1-n1ccnc1

——

(-20℃)

With Ice Pack

≥ 2 years