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TRIM
CAS No. 25371-96-4
TRIM( 1-(2-Trifluoromethylphenyl)imidazole )
Catalog No. M22394 CAS No. 25371-96-4
TRIM is an inhibitor of nNOS.TRIM is a poor inhibitor of bovine aortic endothelial NOS with an IC50 of 1057.5 microM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 25MG | 30 | In Stock |
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| 50MG | 42 | In Stock |
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| 100MG | 61 | In Stock |
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| 500MG | 149 | In Stock |
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| 1G | Get Quote | In Stock |
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| 1 mL x 10 mM in DMSO | 29 | In Stock |
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| 50MG | 28 | In Stock |
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| 100MG | 38 | In Stock |
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| 200MG | 55 | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameTRIM
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NoteResearch use only, not for human use.
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Brief DescriptionTRIM is an inhibitor of nNOS.TRIM is a poor inhibitor of bovine aortic endothelial NOS with an IC50 of 1057.5 microM.
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DescriptionTRIM is an inhibitor of nNOS.TRIM is a poor inhibitor of bovine aortic endothelial NOS with an IC50 of 1057.5 microM. TRIM (10-50 mg kg-1) administered i.p. exhibits dose-related antinociceptive activity in the mouse (assessed as inhibition of late phase formalin-induced hindpaw licking behaviour) with an ED50 of 85.8 mumol kg-1. In contrast, TRIM (50 mg kg-1, i.p.) failed to influence mean arterial blood pressure in the urethane-anaesthetized mouse.
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In VitroTRIM is a relatively weak inhibitor of eNOS (IC50, 1057.5 μM).
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In Vivo——
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Synonyms1-(2-Trifluoromethylphenyl)imidazole
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PathwayImmunology/Inflammation
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TargetNOS
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RecptornNOS
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Research Area——
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Indication——
Chemical Information
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CAS Number25371-96-4
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Formula Weight212.17
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Molecular FormulaC10H7F3N2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 250 mg/mL (1178.30 mM)
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SMILESFC(F)(F)c1ccccc1-n1ccnc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Handy R L C , Wallace P , Gaffen Z A , et al. The antinociceptive effect of 1-(2-trifluoromethylphenyl) imidazole (TRIM), a potent inhibitor of neuronal nitric oxide synthase in vitro, in the mouse.[J]. British Journal of Pharmacology, 2012, 116(5):2349-2350.
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