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TRIM

CAS No. 25371-96-4

TRIM( 1-(2-Trifluoromethylphenyl)imidazole )

Catalog No. M22394 CAS No. 25371-96-4

TRIM is an inhibitor of nNOS.TRIM is a poor inhibitor of bovine aortic endothelial NOS with an IC50 of 1057.5 microM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 29 In Stock
50MG 28 In Stock
100MG 38 In Stock
200MG 55 In Stock
500MG Get Quote In Stock
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Biological Information

  • Product Name
    TRIM
  • Note
    Research use only, not for human use.
  • Brief Description
    TRIM is an inhibitor of nNOS.TRIM is a poor inhibitor of bovine aortic endothelial NOS with an IC50 of 1057.5 microM.
  • Description
    TRIM is an inhibitor of nNOS.TRIM is a poor inhibitor of bovine aortic endothelial NOS with an IC50 of 1057.5 microM. TRIM (10-50 mg kg-1) administered i.p. exhibits dose-related antinociceptive activity in the mouse (assessed as inhibition of late phase formalin-induced hindpaw licking behaviour) with an ED50 of 85.8 mumol kg-1. In contrast, TRIM (50 mg kg-1, i.p.) failed to influence mean arterial blood pressure in the urethane-anaesthetized mouse.
  • In Vitro
    TRIM is a relatively weak inhibitor of eNOS (IC50, 1057.5 μM).
  • In Vivo
    ——
  • Synonyms
    1-(2-Trifluoromethylphenyl)imidazole
  • Pathway
    Immunology/Inflammation
  • Target
    NOS
  • Recptor
    nNOS
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    25371-96-4
  • Formula Weight
    212.17
  • Molecular Formula
    C10H7F3N2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 250 mg/mL (1178.30 mM)
  • SMILES
    FC(F)(F)c1ccccc1-n1ccnc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Handy R L C , Wallace P , Gaffen Z A , et al. The antinociceptive effect of 1-(2-trifluoromethylphenyl) imidazole (TRIM), a potent inhibitor of neuronal nitric oxide synthase in vitro, in the mouse.[J]. British Journal of Pharmacology, 2012, 116(5):2349-2350.
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