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LIN28 inhibitor LI71
CAS No. 1357248-83-9
LIN28 inhibitor LI71( —— )
Catalog No. M22370 CAS No. 1357248-83-9
LIN28 inhibitor LI71 is a potent and cell-permeable LIN28 inhibitor, which abolishes LIN28-mediated oligouridylation with an IC50 of 7 uM.LIN28 inhibitor LI71 directly binds the cold shock domain (CSD) to suppress LIN28’s activity against let-7 in leukemia cells and embryonic stem cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 314 | In Stock |
|
| 10MG | 524 | In Stock |
|
| 25MG | 840 | In Stock |
|
| 50MG | 1143 | In Stock |
|
| 100MG | 1521 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameLIN28 inhibitor LI71
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NoteResearch use only, not for human use.
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Brief DescriptionLIN28 inhibitor LI71 is a potent and cell-permeable LIN28 inhibitor, which abolishes LIN28-mediated oligouridylation with an IC50 of 7 uM.LIN28 inhibitor LI71 directly binds the cold shock domain (CSD) to suppress LIN28’s activity against let-7 in leukemia cells and embryonic stem cells.
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DescriptionLIN28 inhibitor LI71 is a potent and cell-permeable LIN28 inhibitor, which abolishes LIN28-mediated oligouridylation with an IC50 of 7 uM.LIN28 inhibitor LI71 directly binds the cold shock domain (CSD) to suppress LIN28’s activity against let-7 in leukemia cells and embryonic stem cells.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayChromatin/Epigenetic
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TargetMicroRNA
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RecptorLIN28
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Research Area——
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Indication——
Chemical Information
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CAS Number1357248-83-9
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Formula Weight335.4
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Molecular FormulaC21H21NO3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (298.15 mM)
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SMILESO=C(O)C1=CC=C([C@@H]2NC3=C(C=CC=C3OCC)[C@@]4([H])[C@]2([H])CC=C4)C=C1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Wang L, et al. Small-Molecule Inhibitors Disrupt let-7 Oligouridylation and Release the Selective Blockade of let-7 Processing by LIN28. Cell Rep. 2018 Jun 5;23(10):3091-3101.
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