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Tenilsetam
CAS No. 86696-86-8
Tenilsetam( Piperazinone,3-(2-thienyl)- (9CI) )
Catalog No. M22229 CAS No. 86696-86-8
Tenilsetam is an endonuclease modulator; a nootropic agent and advanced glycation end product (AGE) inhibitor having potential for Alzheimer's disease (AD) treatment.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 98 | In Stock |
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| 5MG | 119 | In Stock |
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| 10MG | 181 | In Stock |
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| 25MG | 297 | In Stock |
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| 50MG | 410 | In Stock |
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| 100MG | 554 | In Stock |
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| 200MG | 736 | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameTenilsetam
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NoteResearch use only, not for human use.
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Brief DescriptionTenilsetam is an endonuclease modulator; a nootropic agent and advanced glycation end product (AGE) inhibitor having potential for Alzheimer's disease (AD) treatment.
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DescriptionTenilsetam is an endonuclease modulator; a nootropic agent and advanced glycation end product (AGE) inhibitor having potential for Alzheimer's disease (AD) treatment.In vitro, tenilsetam inhibited endothelial proliferation at lower doses, while inducing apoptosis at high doses. Leucocyte adhesion was only inhibited at high doses. Sprouting angiogenesis of bovine retinal endothelial cells was promoted at lower doses (< or = 10 mM). At micromolar concentrations, endothelial VEGF expression was upregulated by 100%. Long-term treatment with the AGE-inhibitor and iron-chelating compound tenilsetam inhibits the formation of acellular capillaries without correcting pericyte loss. The compound has dose-dependent effects on endothelial cell function.
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In Vitro——
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In Vivo——
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SynonymsPiperazinone,3-(2-thienyl)- (9CI)
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PathwayOthers
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TargetOther Targets
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RecptorAGE
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Research Area——
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Indication——
Chemical Information
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CAS Number86696-86-8
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Formula Weight182.24
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Molecular FormulaC8H10N2OS
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C1NCCN[C@]1([H])c2ccc[s]2
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Jennifer Hoffmann , Alex Alt, Jihong Lin, Günther Lochnit,et al. Tenilsetam prevents early diabetic retinopathy without correcting pericyte loss.Thromb Haemost. 2006 Apr;95(4):689-95.
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