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NSC 65809

CAS No. 94023-67-3

NSC 65809( 3-[(2,3-dichlorophenyl)methylene]carbazamidine )

Catalog No. M22219 CAS No. 94023-67-3

Raphin1 is a selective inhibitor of R15B.In cells, Raphin1 caused a rapid and transient accumulation of its phosphorylated substrate, resulting in a transient attenuation of protein synthesis.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 152 In Stock
5MG 170 In Stock
10MG 258 In Stock
25MG 426 In Stock
50MG 586 In Stock
100MG 792 In Stock
200MG 1051 In Stock
500MG Get Quote In Stock
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Biological Information

  • Product Name
    NSC 65809
  • Note
    Research use only, not for human use.
  • Brief Description
    Raphin1 is a selective inhibitor of R15B.In cells, Raphin1 caused a rapid and transient accumulation of its phosphorylated substrate, resulting in a transient attenuation of protein synthesis.
  • Description
    Raphin1 is a selective inhibitor of R15B.In cells, Raphin1 caused a rapid and transient accumulation of its phosphorylated substrate, resulting in a transient attenuation of protein synthesis. In vitro, Raphin1 inhibits the recombinant R15B-PP1c holoenzyme, but not the closely related R15A-PP1c, by interfering with substrate recruitmentRaphin1 was orally bioavailable, crossed the blood-brain barrier, and demonstrated efficacy in a mouse model of Huntington's disease.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    3-[(2,3-dichlorophenyl)methylene]carbazamidine
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    R15B
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    94023-67-3
  • Formula Weight
    231.08
  • Molecular Formula
    C8H8Cl2N4
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    NC(=N)N/N=C/c1cccc([Cl])c1[Cl]
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Agnieszka Krzyzosiak, Anna Sigurdardottir, Laura Luh.et al.Target-Based Discovery of an Inhibitor of the Regulatory Phosphatase PPP1R15B.Cell. 2018 Aug 23;174(5):1216-1228.e19.
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