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NSC 65809
CAS No. 94023-67-3
NSC 65809( 3-[(2,3-dichlorophenyl)methylene]carbazamidine )
Catalog No. M22219 CAS No. 94023-67-3
Raphin1 is a selective inhibitor of R15B.In cells, Raphin1 caused a rapid and transient accumulation of its phosphorylated substrate, resulting in a transient attenuation of protein synthesis.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 152 | In Stock |
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| 5MG | 170 | In Stock |
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| 10MG | 258 | In Stock |
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| 25MG | 426 | In Stock |
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| 50MG | 586 | In Stock |
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| 100MG | 792 | In Stock |
|
| 200MG | 1051 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameNSC 65809
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NoteResearch use only, not for human use.
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Brief DescriptionRaphin1 is a selective inhibitor of R15B.In cells, Raphin1 caused a rapid and transient accumulation of its phosphorylated substrate, resulting in a transient attenuation of protein synthesis.
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DescriptionRaphin1 is a selective inhibitor of R15B.In cells, Raphin1 caused a rapid and transient accumulation of its phosphorylated substrate, resulting in a transient attenuation of protein synthesis. In vitro, Raphin1 inhibits the recombinant R15B-PP1c holoenzyme, but not the closely related R15A-PP1c, by interfering with substrate recruitmentRaphin1 was orally bioavailable, crossed the blood-brain barrier, and demonstrated efficacy in a mouse model of Huntington's disease.
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In Vitro——
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In Vivo——
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Synonyms3-[(2,3-dichlorophenyl)methylene]carbazamidine
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PathwayOthers
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TargetOther Targets
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RecptorR15B
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Research Area——
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Indication——
Chemical Information
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CAS Number94023-67-3
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Formula Weight231.08
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Molecular FormulaC8H8Cl2N4
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Purity>98% (HPLC)
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Solubility——
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SMILESNC(=N)N/N=C/c1cccc([Cl])c1[Cl]
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Epimagnolin A
Epimagnolin A is a lignan obtained from the flower buds of Magnolia fargesii, which is traditionally used in Asian medicine for treating headache and nasal congestion.?A herbal compound fargesin obtained from M. fargesii, has exerted anti-inflammatory effects in human monocytic THP-1 cells in the previous study.?it was demonstrated that epimagnolin A reduced phorbol-12-myristate-13-acetate (PMA)-induced IL-6 promoter activity and IL-6 production in human monocytic THP-1 cells.?
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Ac-Angiotensinogen (...
Acetyl angiotensinogen (1-14), porcine is a synthetic peptide and N-terminal acetylated form of Angiotensinogen (1-14) porcine .
