2',5'-Dideoxyadenosine

Research use only, not for human use.

2',5'-Dideoxyadenosine is a potent and non-competitive adenylyl cyclase inhibitor via binding the P-site (IC50: 3 μM).2',5'-Dideoxyadenosine (20-150 mM), like adenosine, dependently and reversibly inhibits the positive inotropic and chronotropic effect of beta-adrenergic stimulation with isoproterenol (8-54 pmol) up to 70% and 50%, respectively.

2',5'-Dideoxyadenosine is a potent and non-competitive adenylyl cyclase inhibitor via binding the P-site (IC50: 3 μM).2',5'-Dideoxyadenosine (20-150 mM), like adenosine, dependently and reversibly inhibits the positive inotropic and chronotropic effect of beta-adrenergic stimulation with isoproterenol (8-54 pmol) up to 70% and 50%, respectively [2]. 2',5'-Dideoxyadenosine (10 μM, 30 min) reduces cAMP production and blocks the phosphorylation of GluA1 at Ser845 induced by carbachol (CCh). 2',5'-Dideoxyadenosine (10 μM, 30 min) blocks CCh-induced increase of phosphorylation of Akt and attenuates CCh-induced phosphorylation of Ser2448 [3].2',5'-Dideoxyadenosine (0.1 mg/kg; i.p.; 15 min pre-treated) fully inhibits the natriuretic, diuretic and K+ and Cl- sparing effect of FrEtOAc in rats.

Western Blot Analysis Cell Line:Primary hippocampal neurons Concentration:10 μM Incubation Time:30 min Result:Reduced cAMP production and blocked the phosphorylation of GluA1 at Ser845 induced by carbachol (CCh).

Animal Model:Male Wistar rats (3-4 months old)Dosage:0.1 mg/kg Administration:IP; 15 min pre-treated Result:Fully inhibited the diuretic, natriuretic and K+ and Cl- sparing effect of Fr?EtOAc in rats.

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Others

Other Targets

Adenylyl cyclase (AC)

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6698-26-6

235.24

C10H13N5O2

>98% (HPLC)

In Vitro:?DMSO : 125 mg/mL (531.37 mM)

C[C@H]1O[C@H](C[C@@H]1O)n1cnc2c(N)ncnc12

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(-20℃)

With Ice Pack

≥ 2 years