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TBOPP
CAS No. 1996629-79-8
TBOPP( —— )
Catalog No. M22123 CAS No. 1996629-79-8
TBOPP is a selective DOCK1 inhibitor (IC50 : 8.4 μM), with anti-tumor activity for broader types of tumors.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 226 | In Stock |
|
| 5MG | 212 | In Stock |
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| 10MG | 269 | In Stock |
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| 25MG | 443 | In Stock |
|
| 50MG | 607 | In Stock |
|
| 100MG | 815 | In Stock |
|
| 200MG | 1097 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameTBOPP
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NoteResearch use only, not for human use.
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Brief DescriptionTBOPP is a selective DOCK1 inhibitor (IC50 : 8.4 μM), with anti-tumor activity for broader types of tumors.
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DescriptionTBOPP is a selective DOCK1 inhibitor (IC50 : 8.4 μM), with anti-tumor activity for broader types of tumors. TBOPP as a selective inhibitor of DOCK1. TBOPP dampened DOCK1-mediated invasion, macropinocytosis, and survival under the condition of glutamine deprivation without impairing the biological functions of the closely related DOCK2 and DOCK5 proteins.TBOPP treatment suppressed cancer metastasis and growth in vivo in mice.
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In VitroCell Viability Assay Cell Line:3LL cells Concentration:12.5 μM Incubation Time:3 days Result:Inhibited cell viability.
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In VivoAnimal Model:C57BL/6 mice (6- to 8-week-old) with ex-3LL cells Dosage:0.67 mg per mouse Administration:Administrated on days 0, 1, 3, and 5; for 2 weeks Result:The lung metastasis was significantly suppressed.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorDOCK1|DOCK1 DHR-2 domain
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Research Area——
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Indication——
Chemical Information
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CAS Number1996629-79-8
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Formula Weight490.49
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Molecular FormulaC24H21F3N2O4S
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Purity>98% (HPLC)
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SolubilityDMSO:120 mg/mL (244.65 mM; Need ultrasonic)
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SMILESFC(F)(F)c1cccc(c1)-c1ccc(cc1)C(=O)Cn1cc(ccc1=O)S(=O)(=O)N1CCCC1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Tajiri H, et al. Targeting Ras-Driven Cancer Cell Survival and Invasion through Selective Inhibition of DOCKCell Rep. 2017 May 2;19(5):969-980.
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