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FEN1 Inhibitor C2
CAS No. 1995893-58-7
FEN1 Inhibitor C2( FEN1-IN-4 )
Catalog No. M22114 CAS No. 1995893-58-7
FEN1-IN-4 is an inhibitor of human flap endonuclease-1 (hFEN1)FEN1 Inhibitor C2 inhibition selectively impairs proliferation of colon cancer cells deficient in Cdc4 and Mre11a, both frequently mutated in colorectal cancers.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 93 | In Stock |
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| 2MG | 54 | In Stock |
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| 5MG | 85 | In Stock |
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| 10MG | 136 | In Stock |
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| 25MG | 240 | In Stock |
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| 50MG | 369 | In Stock |
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| 100MG | 570 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameFEN1 Inhibitor C2
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NoteResearch use only, not for human use.
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Brief DescriptionFEN1-IN-4 is an inhibitor of human flap endonuclease-1 (hFEN1)FEN1 Inhibitor C2 inhibition selectively impairs proliferation of colon cancer cells deficient in Cdc4 and Mre11a, both frequently mutated in colorectal cancers.
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DescriptionFEN1-IN-4 is an inhibitor of human flap endonuclease-1 (hFEN1)FEN1 Inhibitor C2 inhibition selectively impairs proliferation of colon cancer cells deficient in Cdc4 and Mre11a, both frequently mutated in colorectal cancers. FEN1 has also emerged as a potential chemosensitizing target due to its role in LP-BER since it is critical for repair of MMS (methyl methanesulfonate)-induced alkylation damage, and its knockdown or inhibition increases sensitivity to TMZ (temozolomide) in glioblastoma and colorectal cancer cell lines.
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In VitroFEN1 inhibition selectively impairs proliferation of colon cancer cells deficient in Cdc4 and Mre11a, both frequently mutated in colorectal cancers. FEN1 has also emerged as a potential chemosensitizing target due to its role in LP-BER since it is critical for repair of Methyl methanesulfonate-induced alkylation damage, and its knockdown or inhibition increases sensitivity to Temozolomide in glioblastoma and colorectal cancer cell lines.
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In Vivo——
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SynonymsFEN1-IN-4
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PathwayOthers
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TargetOther Targets
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RecptorhFEN1
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Research Area——
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Indication——
Chemical Information
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CAS Number1995893-58-7
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Formula Weight232.24
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Molecular FormulaC12H12N2O3
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Purity>98% (HPLC)
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SolubilityDMSO:100 mg/mL (430.59 mM; Need ultrasonic)
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SMILESOn1c(=O)n(CC2CC2)c2ccccc2c1=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Jack C Exell, et al. Cellularly Active N-hydroxyurea FEN1 Inhibitors Block Substrate Entry to the Active Site. Nat Chem Biol. 2016 Oct;12(10):815-21.
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