GAK inhibitor 49( —— )

Catalog No. M22093 CAS No. 319492-82-5

GAK inhibitor 49 is a highly selective and ATP-competitive cyclin G associated kinase (GAK) inhibitor (IC50: 56 nM; Ki: 0.54 nM ).

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	130	In Stock
5MG	113	In Stock
10MG	187	In Stock
25MG	315	In Stock
50MG	445	In Stock
100MG	607	In Stock
200MG	817	In Stock
500MG	Get Quote	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

GAK inhibitor 49
Note

Research use only, not for human use.
Brief Description

GAK inhibitor 49 is a highly selective and ATP-competitive cyclin G associated kinase (GAK) inhibitor (IC50: 56 nM; Ki: 0.54 nM ).
Description

GAK inhibitor 49 is a highly selective and ATP-competitive cyclin G associated kinase (GAK) inhibitor (IC50: 56 nM; Ki: 0.54 nM ).
In Vitro

GAK inhibitor 49 (compound 49) shows a weak inhibitory effect on AAK1, BMP2K and STK16, with IC50s of 28, 63 and >100 μM, respectively.
In Vivo

——
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

GAK
Research Area

——
Indication

——

Chemical Information

CAS Number

319492-82-5
Formula Weight

370.4
Molecular Formula

C20H22N2O5?
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 50 mg/mL (134.99 mM)
SMILES

COc1cc2nccc(Nc3cc(OC)c(OC)c(OC)c3)c2cc1OC
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Asquith CRM, et al. Identification and Optimization of 4-Anilinoquinolines as Inhibitors of Cyclin G Associated Kinase. ChemMedChem. 2018;13(1):48-66.

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