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LQZ-7I

CAS No. 195822-23-2

LQZ-7I( —— )

Catalog No. M22010 CAS No. 195822-23-2

LQZ-7I is an inhibitor of surviving-targeting. It orally effectively inhibits xenograft tumor growth and induces survivin loss in tumors.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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10MG 72 Get Quote
25MG 147 Get Quote
50MG 237 Get Quote
100MG 372 Get Quote
500MG 849 Get Quote
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Biological Information

  • Product Name
    LQZ-7I
  • Note
    Research use only, not for human use.
  • Brief Description
    LQZ-7I is an inhibitor of surviving-targeting. It orally effectively inhibits xenograft tumor growth and induces survivin loss in tumors.
  • Description
    LQZ-7I is an inhibitor of surviving-targeting. It orally effectively inhibits xenograft tumor growth and induces survivin loss in tumors.
  • In Vitro
    Western Blot Analysis Cell Line:PC-3 or C4-2 cells Concentration:10 μM Incubation Time:0-6 hours Result:Reduced the expression of survivin.
  • In Vivo
    Animal Model:6-week old male NSG mice Dosage:100 mg/kg; 200 μL vehicle (90% corn oil/10% DMSO) Administration:Oral gavage every other day for a total of ten treatments Result:Significantly suppressed tumor growth without any notable adverse effect on the mice as indicated by lacking changes in body weight and in wet weight of major organs at the end of the study.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Survivin
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    195822-23-2
  • Formula Weight
    348.35
  • Molecular Formula
    C20H14F2N4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:120mg/ml (344.48 Mm; Need ultrasonic)
  • SMILES
    FC1=CC=C(NC2=NC3=CC=CC=C3N=C2NC2=CC=C(F)C=C2)C=C1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Robert Peery,et al. Synthesis and Identification of a Novel Lead Targeting Survivin Dimerization for Proteasome-Dependent Degradation. J Med Chem. 2020 Jun 9.
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