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Dantrolene
CAS No. 7261-97-4
Dantrolene( —— )
Catalog No. M21969 CAS No. 7261-97-4
Dantrolene is a postsynaptic muscle relaxant by inhibiting Ca2+ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 54 | In Stock |
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| 5MG | 48 | In Stock |
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| 10MG | 70 | In Stock |
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| 25MG | 93 | In Stock |
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| 50MG | 160 | In Stock |
|
| 100MG | 206 | In Stock |
|
| 200MG | 305 | In Stock |
|
| 500MG | 514 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameDantrolene
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NoteResearch use only, not for human use.
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Brief DescriptionDantrolene is a postsynaptic muscle relaxant by inhibiting Ca2+ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors.
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DescriptionDantrolene is a postsynaptic muscle relaxant by inhibiting Ca2+ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors.
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In VitroRT-PCR Cell Line:Porcine aortic valvular interstitial cells (paVICs) Concentration:60 μM Incubation Time:At 1 and 3 days Result:Significantly inhibited ACTA2 expression and upregulated RUNX2 expression.
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In VivoAnimal Model:YAC128 transgenic mice (FVBN/NJ background strain) and WT mice Dosage:5 mg/kg Administration:Fed orally twice per week from 2 to 11.5 months of age Result:Resulted in significantly improved performance in the beam-walking and gait-walking assays. Significantly reduced the loss of NeuN-positive striatal neurons and reduced formation of Httexp nuclear aggregates.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorRyanodine receptor
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Research AreaCerebrovascular system
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IndicationSubarachnoid HemorrhageCerebral Vasospasm
Chemical Information
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CAS Number7261-97-4
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Formula Weight314.25
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Molecular FormulaC14H10N4O5
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : ≥ 20 mg/mL (63.64 mM)
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SMILES[O-][N+](=O)c1ccc(cc1)-c1ccc(C=NN2CC(=O)NC2=O)o1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Diszhazi G , Magyar Z E , Motyan J A , et al. Dantrolene Requires Mg2+ and ATP To Inhibit the Ryanodine Receptor[J]. Molecular Pharmacology, 2019, 96(3):mol.119.116475.
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