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Dantrolene

CAS No. 7261-97-4

Dantrolene( —— )

Catalog No. M21969 CAS No. 7261-97-4

Dantrolene is a postsynaptic muscle relaxant by inhibiting Ca2+ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 54 In Stock
5MG 48 In Stock
10MG 70 In Stock
25MG 93 In Stock
50MG 160 In Stock
100MG 206 In Stock
200MG 305 In Stock
500MG 514 In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    Dantrolene
  • Note
    Research use only, not for human use.
  • Brief Description
    Dantrolene is a postsynaptic muscle relaxant by inhibiting Ca2+ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors.
  • Description
    Dantrolene is a postsynaptic muscle relaxant by inhibiting Ca2+ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors.
  • In Vitro
    RT-PCR Cell Line:Porcine aortic valvular interstitial cells (paVICs) Concentration:60 μM Incubation Time:At 1 and 3 days Result:Significantly inhibited ACTA2 expression and upregulated RUNX2 expression.
  • In Vivo
    Animal Model:YAC128 transgenic mice (FVBN/NJ background strain) and WT mice Dosage:5 mg/kg Administration:Fed orally twice per week from 2 to 11.5 months of age Result:Resulted in significantly improved performance in the beam-walking and gait-walking assays. Significantly reduced the loss of NeuN-positive striatal neurons and reduced formation of Httexp nuclear aggregates.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Ryanodine receptor
  • Research Area
    Cerebrovascular system
  • Indication
    Subarachnoid HemorrhageCerebral Vasospasm

Chemical Information

  • CAS Number
    7261-97-4
  • Formula Weight
    314.25
  • Molecular Formula
    C14H10N4O5
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : ≥ 20 mg/mL (63.64 mM)
  • SMILES
    [O-][N+](=O)c1ccc(cc1)-c1ccc(C=NN2CC(=O)NC2=O)o1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Diszhazi G , Magyar Z E , Motyan J A , et al. Dantrolene Requires Mg2+ and ATP To Inhibit the Ryanodine Receptor[J]. Molecular Pharmacology, 2019, 96(3):mol.119.116475.
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