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Butoconazole

CAS No. 64872-76-0

Butoconazole( 1-[4-(4-chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]-1H-imidazole )

Catalog No. M21968 CAS No. 64872-76-0

Butoconazole is an imidazole antifungal agentButoconazole is particularly effective against in vivo Candida albicans infections (mice), maintaining good activity down to 0.25% formulation strength and showing unusually low reinfection rates after treatment is ended.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Butoconazole
  • Note
    Research use only, not for human use.
  • Brief Description
    Butoconazole is an imidazole antifungal agentButoconazole is particularly effective against in vivo Candida albicans infections (mice), maintaining good activity down to 0.25% formulation strength and showing unusually low reinfection rates after treatment is ended.
  • Description
    Butoconazole is an imidazole antifungal agentButoconazole is particularly effective against in vivo Candida albicans infections (mice), maintaining good activity down to 0.25% formulation strength and showing unusually low reinfection rates after treatment is ended.Butoconazole 1-BSR is an effective and safe alternative to longer-term therapy with miconazole nitrate (seven days) for vulvovaginal candidiasis.
  • In Vitro
    Imidazoles generally inhibit the conversion of lanosterol to ergosterol, resulting in a change in fungal cell membrane lipid composition. This structural change alters cell permeability and, ultimately, results in the osmotic disruption or growth inhibition of the fungal cell.
  • In Vivo
    ——
  • Synonyms
    1-[4-(4-chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]-1H-imidazole
  • Pathway
    Microbiology/Virology
  • Target
    Antifungal
  • Recptor
    Antifungal
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    64872-76-0
  • Formula Weight
    411.76
  • Molecular Formula
    C19H17Cl3N2S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:77 mg/ml(187 mM)
  • SMILES
    Clc1ccc(CCC(Cn2ccnc2)Sc2c(Cl)cccc2Cl)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Walker K A M , Braemer A C , Hitt S , et al. 1-[4-(4-Chlorophenyl)-2-(2,6-dichlorophenylthio)-n-butyl]-1H-imidazole nitrate, a new potent antifungal agent[J]. Journal of Medicinal Chemistry, 1978, 21(8):840-843.2. Brown D , Henzl M R , Kaufman R H . Butoconazole nitrate 2% for vulvovaginal candidiasis. New, single-dose vaginal cream formulation vs. seven-day treatment with miconazole nitrate. Gynazole 1 Study Group[J]. Journal of Reproductive Medicine, 1999, 44(11):933-938.
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