Bakuchiol

Research use only, not for human use.

Bakuchiol is a phytoestrogen isolated from the seeds of Psoralea corylifolia L; has anti-tumor effects.

Bakuchiol is a phytoestrogen isolated from the seeds of Psoralea corylifolia L; has anti-tumor effects. IC50 value: Target: in vitro: Bakuchiol reduced mitochondrial membrane potential (Psim) of cells in a concentration- and time-dependent manner, showing a more potent effect than that of resveratrol. S phase arrest, caspase 9/3 activaton, p53 and Bax up-regulation, as well as Bcl-2 down-regulation were observed in bakuchiol-treated A549 cells. UGT2B7 was inhibited by the strongest intensity. The noncompetitive inhibition was demonstrated by the results obtained from Dixon plot and Lineweaver-Burk plot. The Ki value was calculated to be 10.7 μM. Bakuchiol was found to be naturally occurring potent inhibitors of hCE2, with low Ki values ranging from 0.62μM to 3.89μM.

——

——

(S)-(+)-Bakuchiol

MAPK/ERK Signaling

p38 MAPK

——

——

——

10309-37-2

256.38

C??H??O

>98% (HPLC)

DMSO : 62.5 mg/mL (243.78 mM; Need ultrasonic);H2O : < 0.1 mg/mL (insoluble)

OC1=CC=C(/C=C/[C@](C)(C=C)CC/C=C(C)\C)C=C1

——

(-20℃)

With Ice Pack

≥ 2 years