Retrorsine

Research use only, not for human use.

Retrorsine is a naturally occurring toxic pyrrolizidine alkaloid. Retrorsine can bind with DNA and inhibits the proliferative capacity of hepatocytes.

Retrorsine is a naturally occurring toxic pyrrolizidine alkaloid. Retrorsine can bind with DNA and inhibits the proliferative capacity of hepatocytes.

Retrorsine (60-240 μM; 24 hours) significantly reduces HSEC-CYP3A4 cells viability and GSH levels, and increases formation of pyrrole-protein adducts. Cell Viability Assay Cell Line:HSEC-CYP3A4 cells Concentration:60 μM, 120 μM , 240 μM Incubation Time:24 hours Result:Significantly decreased cell viability.

Retrorsine (30 mg/kg; i.p.; twice) impairs liver regeneration in the PBL model not only by an S or G2/M phase block, but also by a block located before the G1/S transition of the cell cycle. Animal Model:Male Wistar rats (180±20 g), portal branch ligation (PBL) modelDosage:30 mg/kgAdministration:Intraperitoneal injection, twice, separated by 2-week intervalResult:Strongly impaired the liver weight gain, protein and DNA synthesis as well as induction of cell cycle related proteins in the regenerating lobes after PBL.

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Others

Other Targets

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480-54-6

351.39

C??H??NO?

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (284.58 mM)

O=C(O[C@]1([H])CCN2[C@]1([H])C(COC([C@](CO)(O)[C@H](C)C/3)=O)=CC2)C3=C/C

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(-20℃)

With Ice Pack

≥ 2 years