Cart
sales@molnova.com
Home - Products - Metabolic Enzyme/Protease - Other Targets - SI-113

SI-113

CAS No. 1392816-46-4

SI-113 ( —— )

Catalog No. M21730 CAS No. 1392816-46-4

SI-113(SI113;SI 113) is a potent, specific inhibitor of the SGK1 kinase activity, induces autophagy, apoptosis and ER stress in cancer cells.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 49 In Stock
5MG 80 In Stock
10MG 129 In Stock
25MG 237 In Stock
50MG 354 In Stock
100MG 518 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    SI-113
  • Note
    Research use only, not for human use.
  • Brief Description
    SI-113(SI113;SI 113) is a potent, specific inhibitor of the SGK1 kinase activity, induces autophagy, apoptosis and ER stress in cancer cells.
  • Description
    SI-113(SI113;SI 113) is a potent, specific inhibitor of the SGK1 kinase activity, induces autophagy, apoptosis and ER stress in cancer cells; blocks insulin-dependent phosphorylation of the Sgk1 substrate Mdm2, and induces necrosis and apoptosis in RKO cells; potentiates the effects of paclitaxel on cell viability; active in vivo.
  • In Vitro
    SI-113 exhibits IC50 values of 10.5, 14.4 and 10.7 μM in GIN8, GIN28 and GCE28 GBM cells.SI-113 induces significant increases in caspase-3/7 activation in all GBM cell lines.SI-113 induces autophagy and synergizes with quinacrine in hindering the growth of human glioblastoma multiforme cells.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    Other Targets
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1392816-46-4
  • Formula Weight
    400.486
  • Molecular Formula
    C23H24N6O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 250 mg/mL (624.25 mM)
  • SMILES
    ——
  • Chemical Name
    2-((4-(phenethylamino)-1-styryl-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)ethan-1-ol

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. D'Antona L, et al. Cell Physiol Biochem. 2015;35(5):2006-18. 2. Talarico C, et al. Oncotarget. 2015 Nov 10;6(35):37511-25. 3. Talarico C, et al. Oncotarget. 2016 Mar 29;7(13):15868-84. 4. Radi M, et al. J Med Chem. 2011 Apr 28;54(8):2610-26.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • Thermopsoside

    Thermopsoside is a flavone derivative isolated from Aspalathus linearis.

  • Risedronic Acid

    Risedronic acid (Risedronate ) is a pyridinyl biphosphonate which inhibits osteoclast-mediated bone resorption.

  • Seneciphylline

    Seneciphylline is a toxic pyrrolizidine alkaloid in Senecio plants. Seneciphylline significantly increases the activities of epoxide hydrase and glutathione-S-transferase but causes reduction of cytochrome P-450 and related monooxygenase activities.

Sign In Join Free