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SI-113
CAS No. 1392816-46-4
SI-113 ( —— )
Catalog No. M21730 CAS No. 1392816-46-4
SI-113(SI113;SI 113) is a potent, specific inhibitor of the SGK1 kinase activity, induces autophagy, apoptosis and ER stress in cancer cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 103 | In Stock |
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| 2MG | 51 | In Stock |
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| 5MG | 85 | In Stock |
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| 10MG | 136 | In Stock |
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| 25MG | 250 | In Stock |
|
| 50MG | 365 | In Stock |
|
| 100MG | 536 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSI-113
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NoteResearch use only, not for human use.
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Brief DescriptionSI-113(SI113;SI 113) is a potent, specific inhibitor of the SGK1 kinase activity, induces autophagy, apoptosis and ER stress in cancer cells.
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DescriptionSI-113(SI113;SI 113) is a potent, specific inhibitor of the SGK1 kinase activity, induces autophagy, apoptosis and ER stress in cancer cells; blocks insulin-dependent phosphorylation of the Sgk1 substrate Mdm2, and induces necrosis and apoptosis in RKO cells; potentiates the effects of paclitaxel on cell viability; active in vivo.
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In VitroSI-113 exhibits IC50 values of 10.5, 14.4 and 10.7 μM in GIN8, GIN28 and GCE28 GBM cells.SI-113 induces significant increases in caspase-3/7 activation in all GBM cell lines.SI-113 induces autophagy and synergizes with quinacrine in hindering the growth of human glioblastoma multiforme cells.
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In Vivo——
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Synonyms——
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PathwayMetabolic Enzyme/Protease
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TargetOther Targets
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number1392816-46-4
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Formula Weight400.486
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Molecular FormulaC23H24N6O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 250 mg/mL (624.25 mM)
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SMILES——
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Chemical Name2-((4-(phenethylamino)-1-styryl-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)ethan-1-ol
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. D'Antona L, et al. Cell Physiol Biochem. 2015;35(5):2006-18.
2. Talarico C, et al. Oncotarget. 2015 Nov 10;6(35):37511-25.
3. Talarico C, et al. Oncotarget. 2016 Mar 29;7(13):15868-84.
4. Radi M, et al. J Med Chem. 2011 Apr 28;54(8):2610-26.
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