BMS-2( —— )

Catalog No. M21662 CAS No. 888719-03-7

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

BMS-2
Note

Research use only, not for human use.
Brief Description

BMS-2 is a Met/Flt-3/VEGFR2 tyrosine kinase inhibitor.
Description

BMS-2 is a Met/Flt-3/VEGFR2 tyrosine kinase inhibitor.
In Vitro

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In Vivo

Animal Model:MiceDosage:5, 10 mg/kg Administration:IV, POResult:Showed extensive extravascular distribution and a favorable half-life.Animal Model:Nude mice Dosage:6.25, 12.5, 25 and 50 mg/kg Administration:PO, once a day Result:Showed antitumor activity in dose-dependet.
Synonyms

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Pathway

Angiogenesis
Target

c-Met/HGFR
Recptor

Met|FLT3|VEGFR2
Research Area

——
Indication

——

CAS Number

888719-03-7
Formula Weight

458.42
Molecular Formula

C25H16F2N4O3
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (218.14 mM)
SMILES

Fc1ccc(cc1)-n1cccc(C(=O)Nc2ccc(Oc3ccnc4[nH]ccc34)c(F)c2)c1=O
Chemical Name

1-(4-Fluorophenyl)-N-[3-fluoro-4-(1H-pyrrolo[23-b]pyridin-4-yloxy)phenyl]-2-oxopyridine-3-carboxamide