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OGG1-IN-O8
CAS No. 350997-39-6
OGG1-IN-O8( —— )
Catalog No. M21645 CAS No. 350997-39-6
OGG1-IN-O8 is an inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1;IC50 : 0.35 μM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 52 | In Stock |
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| 5MG | 46 | In Stock |
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| 10MG | 81 | In Stock |
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| 25MG | 158 | In Stock |
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| 50MG | 230 | In Stock |
|
| 100MG | 343 | In Stock |
|
| 200MG | 514 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameOGG1-IN-O8
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NoteResearch use only, not for human use.
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Brief DescriptionOGG1-IN-O8 is an inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1;IC50 : 0.35 μM).
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DescriptionOGG1-IN-O8 is an inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1;IC50 : 0.35 μM).
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In VitroOGG1-IN-08 (50 μM) inhibits different DNA glycosylases activities, it inhibits?nei endonuclease VIII-like 1 DNA glycosylase (NEIL1)(84.56%), endonuclease III-like (NTH1)(63.09%), andFpg (91.74%), respectively.OGG1-IN-08 (10 μM) has a inhibitory OGG1 lyase activity on a substrate containing an AP site compared with the no inhibitor control.OGG1-IN-08 (10 μM) decreases the number of bases released into solution by OGG1 for both the 8-oxo-Gua and FapyGua compared with the no inhibitor.
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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Recptor8-oxoguanine DNA glycosylase 1 (OGG1)
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Research Area——
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Indication——
Chemical Information
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CAS Number350997-39-6
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Formula Weight261.12
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Molecular FormulaC9H6Cl2N2OS
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 25 mg/mL (95.74 mM)
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SMILESNNC(=O)c1sc2cccc(Cl)c2c1Cl
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Chemical Name34-Dichloro-benzo[b]thiophene-2-carboxylic acid hydrazide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Lloyd R.S. Mccullough A.K. and Donley N.?Small molecule inhibitors of 8-oxoguanine DNA glycosylase-1 (OGG1).?(2016).
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