Cefazolin

Research use only, not for human use.

Cefazolin is a semi-synthetic cephalosporin that has a broad spectrum of antibacterial activity and inhibits the synthesis of bacterial cell walls.

Cefazolin is a semi-synthetic cephalosporin that has a broad spectrum of antibacterial activity and inhibits the synthesis of bacterial cell walls.

Cell Viability Assa yCell Line:C8-B4 cellsConcentration:0, 50, 100, 150, 200, 250, or 300 μg/mlIncubation Time:6 or 24 hoursResult:Inhibited the increase of IL-1β at all doses, but inhibited the increase of IL-6 only at 200 μg/ml.Cell Proliferation Assay Cell Line:PBMC, and TF-1 cells Concentration:0, 100, 200, and 400 μM Incubation Time:72 hours Result:Reduced IL-2, IL-4 and IL-15-induced cell proliferation, suggested that Cefazolin interferes not only with IL-15Rα, but also with IL-2/IL-15Rβ and/or γc.Cell Proliferation Assay Cell Line:PBMC, NK-92, and TF-1 cells Concentration:0, 100, 200, and 400 μM Incubation Time:30 min Result:Diminished the phosphorylation of JAK3 in response to the cytokine treatment, concluded suppressing signal transduction by γc receptors.

Animal Model:6- to 8-week-old male CD-1 mice underwent clinical exploratory laparotomy Dosage:300-500 mg/kg Administration:Subcutaneous injection; 300-500 mg/kg; once daily; 5 days Result:Attenuated learning and memory dysfunction induced by the surgery.

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Others

Other Targets

Others

Infection

InfectionCesarean; DeliveryAntibiotic; Prophylaxis

25953-19-9

454.51

C14H14N8O4S3

>98% (HPLC)

DMSO:91 mg/mL (200.22 mM)

[H][C@]12SCC(CSc3nnc(C)s3)=C(N1C(=O)[C@H]2NC(=O)Cn1cnnn1)C(O)=O

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(-20℃)

With Ice Pack

≥ 2 years