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5'-Fluoroindirubinoxime
CAS No. 861214-33-7
5'-Fluoroindirubinoxime( 5'-FIO )
Catalog No. M21594 CAS No. 861214-33-7
5'-Fluoroindirubinoxime is a potent FLT3 inhibitor( IC50 : 15 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 96 | Get Quote |
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| 5MG | 155 | Get Quote |
|
| 10MG | 260 | Get Quote |
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| 25MG | 338 | Get Quote |
|
| 50MG | 410 | Get Quote |
|
| 100MG | 591 | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product Name5'-Fluoroindirubinoxime
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NoteResearch use only, not for human use.
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Brief Description5'-Fluoroindirubinoxime is a potent FLT3 inhibitor( IC50 : 15 nM).
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Description5'-Fluoroindirubinoxime is a potent FLT3 inhibitor( IC50 : 15 nM).
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In Vitro5'-Fluoroindirubinoxime (5’-FIO, compound 13) exhibits IC50 values of 1.53 μM and 1.27 μM for VEGFR2 and Aurora A, respectively.5'-Fluoroindirubinoxime (5’-FIO) exhibits IC50 values of 12.2 μM, 2.1 μM, 3.4 μM and 5.1 μM in A549, SNU-638, HT-1080 and RK3E-ras cancer cells, respectively. 5'-Fluoroindirubinoxime (5’-FIO) induces the apoptosis in RK3E-ras cells.
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In Vivo5'-Fluoroindirubinoxime (5’-FIO, 10 μmol/L/100 μL (~2.95 mg/mL) every other day beginning on day 6, S.C..) exhibits significant anti-tumor activity in rats. Animal Model:Rat tumor model based RK3E-ras cells.Dosage:S.C..Administration:10 μmol/L/100 μL (~2.95 mg/mL) every other day beginning on day 6.Result:Effectively inhibited tumor growth.
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Synonyms5'-FIO
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PathwayAngiogenesis
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TargetFLT
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RecptorFLT3
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Research Area——
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Indication——
Chemical Information
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CAS Number861214-33-7
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Formula Weight295.27
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Molecular FormulaC16H10FN3O2
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Purity>98% (HPLC)
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SolubilityDMSO:83.33 mg/mL (282.22 mM; Need ultrasonic)
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SMILESOc1[nH]c2ccc(F)cc2c1-c1[nH]c2ccccc2c1N=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Kim SA et al. Antitumor activity of novel indirubin derivatives in rat tumor model. Clin Cancer Res. 2007 Jan 1;13(1):253-9.
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