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4-IPP
CAS No. 41270-96-6
4-IPP( 4-Iodo-6-phenylpyrimidine )
Catalog No. M21584 CAS No. 41270-96-6
4-IPP is an irreversible inhibitor of macrophage migration inhibitory factor (MIF).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 56 | In Stock |
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| 2MG | 29 | In Stock |
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| 5MG | 55 | In Stock |
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| 10MG | 93 | In Stock |
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| 25MG | 158 | In Stock |
|
| 50MG | 221 | In Stock |
|
| 100MG | 328 | In Stock |
|
| 200MG | 458 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product Name4-IPP
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NoteResearch use only, not for human use.
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Brief Description4-IPP is an irreversible inhibitor of macrophage migration inhibitory factor (MIF).
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Description4-IPP is an irreversible inhibitor of macrophage migration inhibitory factor (MIF).
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In VitroCell Cytotoxicity Assay Cell Line:BMMs Concentration:0.5 μM, 1 μM, 2.5 μM, 5 μM, 10 μM, 25 μM, 50 μM, 100 μM, 200 μM Incubation Time:24 hours, 72 hours Result:Inhibited osteoclastogenesis in a dose-dependent manner.Western Blot Analysis Cell Line:BMMs Concentration:5 μM,10 μM, 20 μM Incubation Time:1 day, 3 days, 5 days Result:Inhibited RANKL-induced osteoclast differentiation and bone resorption.
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In VivoAnimal Model:8-weeks-old C57BL/6J male mice Dosage:1 mg/kg, 5 mg/kg Administration:Intraperitoneal injection; every 2 days; for 8 weeks Result:Alleviated OVX-induced osteoporosis.
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Synonyms4-Iodo-6-phenylpyrimidine
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PathwayOthers
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TargetOther Targets
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RecptorMIF
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Research Area——
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Indication——
Chemical Information
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CAS Number41270-96-6
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Formula Weight282.08
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Molecular FormulaC10H7IN2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (354.51 mM)
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SMILESIc1cc(ncn1)-c1ccccc1
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Chemical Name4-Iodo-6-phenyl-pyrimidine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Zheng L et al. Macrophage migration inhibitory factor (MIF) inhibitor 4-IPP suppresses osteoclast formation and promotes osteoblast differentiation through the inhibition of the NF-κB signaling pathway. FASEB J. 2019 Jun;33(6):7667-7683.
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