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4-IPP

CAS No. 41270-96-6

4-IPP( 4-Iodo-6-phenylpyrimidine )

Catalog No. M21584 CAS No. 41270-96-6

4-IPP is an irreversible inhibitor of macrophage migration inhibitory factor (MIF).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 56 In Stock
2MG 29 In Stock
5MG 55 In Stock
10MG 93 In Stock
25MG 158 In Stock
50MG 221 In Stock
100MG 328 In Stock
200MG 458 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    4-IPP
  • Note
    Research use only, not for human use.
  • Brief Description
    4-IPP is an irreversible inhibitor of macrophage migration inhibitory factor (MIF).
  • Description
    4-IPP is an irreversible inhibitor of macrophage migration inhibitory factor (MIF).
  • In Vitro
    Cell Cytotoxicity Assay Cell Line:BMMs Concentration:0.5 μM, 1 μM, 2.5 μM, 5 μM, 10 μM, 25 μM, 50 μM, 100 μM, 200 μM Incubation Time:24 hours, 72 hours Result:Inhibited osteoclastogenesis in a dose-dependent manner.Western Blot Analysis Cell Line:BMMs Concentration:5 μM,10 μM, 20 μM Incubation Time:1 day, 3 days, 5 days Result:Inhibited RANKL-induced osteoclast differentiation and bone resorption.
  • In Vivo
    Animal Model:8-weeks-old C57BL/6J male mice Dosage:1 mg/kg, 5 mg/kg Administration:Intraperitoneal injection; every 2 days; for 8 weeks Result:Alleviated OVX-induced osteoporosis.
  • Synonyms
    4-Iodo-6-phenylpyrimidine
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    MIF
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    41270-96-6
  • Formula Weight
    282.08
  • Molecular Formula
    C10H7IN2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (354.51 mM)
  • SMILES
    Ic1cc(ncn1)-c1ccccc1
  • Chemical Name
    4-Iodo-6-phenyl-pyrimidine

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Zheng L et al. Macrophage migration inhibitory factor (MIF) inhibitor 4-IPP suppresses osteoclast formation and promotes osteoblast differentiation through the inhibition of the NF-κB signaling pathway. FASEB J. 2019 Jun;33(6):7667-7683.
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