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SR-4835

CAS No. 2387704-62-1

SR-4835( —— )

Catalog No. M21578 CAS No. 2387704-62-1

SR-4835 is a highly selective dual inhibitor of CDK12 and CDK13(CDK12: IC50=99 nM Kd=98 nM; CDK13: Kd=4.9 nM) which disables triple-negative breast cancer (TNBC) cells.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
2MG	67	In Stock
5MG	110	In Stock
10MG	178	In Stock
25MG	368	In Stock
50MG	536	In Stock
100MG	779	In Stock
500MG	1593	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

SR-4835
Note

Research use only, not for human use.
Brief Description

SR-4835 is a highly selective dual inhibitor of CDK12 and CDK13(CDK12: IC50=99 nM Kd=98 nM; CDK13: Kd=4.9 nM) which disables triple-negative breast cancer (TNBC) cells.
Description

SR-4835 is a highly selective dual inhibitor of CDK12 and CDK13(CDK12: IC50=99 nM Kd=98 nM; CDK13: Kd=4.9 nM) which disables triple-negative breast cancer (TNBC) cells.
In Vitro

Western Blot Analysis Cell Line:MDA-MB-231 cells Concentration:90 nM Incubation Time:0.5, 6, 24, 48 hours Result:Suppressed ATM and RAD51 protein levels.
In Vivo

——
Synonyms

——
Pathway

Angiogenesis
Target

CDK
Recptor

CDK
Research Area

——
Indication

——

Chemical Information

CAS Number

2387704-62-1
Formula Weight

499.36
Molecular Formula

C21H20Cl2N10O
Purity

>98% (HPLC)
Solubility

DMSO:5 mg/mL (10.01 mM; ultrasonic and warming and heat to 60°C)
SMILES

Cn1cc(cn1)-n1cnc2c(NCc3nc4cc(Cl)c(Cl)cc4[nH]3)nc(nc12)N1CCOCC1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Quereda V et al. Therapeutic Targeting of CDK12/CDK13 in Triple-Negative Breast Cancer. Cancer Cell. 2019 Oct 8. pii: S1535-6108(19)30424-6.

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