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Enzalutamide carboxylic acid
CAS No. 1242137-15-0
Enzalutamide carboxylic acid( —— )
Catalog No. M21564 CAS No. 1242137-15-0
Enzalutamide carboxylic acid is an antagonist of androgen receptor (AR) .
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 136 | In Stock |
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| 2MG | 81 | In Stock |
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| 5MG | 122 | In Stock |
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| 10MG | 187 | In Stock |
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| 25MG | 315 | In Stock |
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| 50MG | 431 | In Stock |
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| 100MG | 635 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameEnzalutamide carboxylic acid
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NoteResearch use only, not for human use.
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Brief DescriptionEnzalutamide carboxylic acid is an antagonist of androgen receptor (AR) .
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DescriptionEnzalutamide carboxylic acid is an antagonist of androgen receptor (AR) .
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In VitroEnzalutamide is converted into its major metabolites, N-desmethyl enzalutamide and carboxylic acid enzalutamide, by cytochrome P450 (CYP) 3A4/5 and CYP2C8, respectively. N-desmethyl enzalutamide has clinically relevant anti-androgen capacities similar to enzalutamide, whereas carboxylic acid enzalutamide is inactive.
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In Vivo——
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Synonyms——
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PathwayEndocrinology/Hormones
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TargetAndrogen Receptor (AR)
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RecptorAndrogen Receptor
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Research Areacancer
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Indicationcastration-resistant prostate cancer
Chemical Information
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CAS Number1242137-15-0
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Formula Weight451.4
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Molecular FormulaC20H13F4N3O3S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (276.92 mM)
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SMILESCC1(C)N(C(=S)N(C1=O)c1ccc(C#N)c(c1)C(F)(F)F)c1ccc(C(O)=O)c(F)c1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.van Nuland M et al. Exposure-Response Assessment of Enzalutamide and Its Major Metabolites in a Real-World Cohort of Patients with Metastatic Castration-Resistant Prostate Cancer. Pharmacotherapy. 2019 Dec;39(12):1137-1145.
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