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4'57-Trimethoxyflavone

CAS No. 5631-70-9

4'57-Trimethoxyflavone( —— )

Catalog No. M21520 CAS No. 5631-70-9

574'-Trimethoxyflavone is isolated from Kaempferia parviflora (KP) which is a medicinal plant from Thailand.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    4'57-Trimethoxyflavone
  • Note
    Research use only, not for human use.
  • Brief Description
    574'-Trimethoxyflavone is isolated from Kaempferia parviflora (KP) which is a medicinal plant from Thailand.
  • Description
    574'-Trimethoxyflavone is isolated from Kaempferia parviflora (KP) which is a medicinal plant from Thailand.
  • In Vitro
    Cell Viability Assay Cell Line:AGS, SNU-1, SNU-16Concentration:12.5 ,25, 50, 100, 200 μM Incubation Time:24 and 48 h Result:Showed the highest cytotoxicity in SNU-16 cells.Apoptosis Analysis Cell Line: SNU-16 Concentration:12.5 ,25, 37.5, 50 μM Incubation Time:24 h Result:Increased the percentage of annexin V-positive SNU-16 cells from 7.2% to 58.0% and the expression of GRP78、IRE1a、ATF-4 and CHOP.Western Blot Analysis Cell Line:HDFs Concentration:6.25, 12.5 μM Incubation Time:24 h Result:Inhibited matrix metalloproteinase-1 ( MMP-1) expression and stimulated collagen, type I,and alpha 1 (COLIA1) expression.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Apoptosis
  • Target
    Caspase
  • Recptor
    Caspase-3| PARP
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    5631-70-9
  • Formula Weight
    312.3
  • Molecular Formula
    C18H16O5
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (320.18 mM)
  • SMILES
    COc(cc1)ccc1C(Oc1c2c(OC)cc(OC)c1)=CC2=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Kim H et al. Induction of ER Stress-Mediated Apoptosis by the Major Component 574'-TrimethoxyflavoneIsolated from Kaempferia parviflora Tea Infusion. Nutr Cancer. 2018 Aug-Sep;70(6):984-996.
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