3'-Hydroxypterostilbene

Research use only, not for human use.

3'-Hydroxypterostilbene a natural pterostilbene analogue effectively inhibits the growth of human colon cancer cells with IC50s of 9.0 40.2 and 70.9 μM for COLO 205 HCT-116 and HT-29 cells respectively by inducing apoptosis and autophagy.

3'-Hydroxypterostilbene a natural pterostilbene analogue effectively inhibits the growth of human colon cancer cells with IC50s of 9.0 40.2 and 70.9 μM for COLO 205 HCT-116 and HT-29 cells respectively by inducing apoptosis and autophagy. 3'-Hydroxypterostilbene inhibits the p38MAPK and PI3K/Akt/mTOR/p70S6K pathways and activates the ERK1/2 JNK1/2 MAPK pathways.

Cell Proliferation Assay Cell Line:COLO 205, HCT-116 and HT-29 cell lines Concentration:5, 10, 25 and 50 μM Incubation Time:24 hours Result:Inhibited cell proliferation of COLO 205, HCT-116 and HT-29 cells with IC50s of 9.0, 40.2 and 70.9 μM, respectively.Apoptosis Analysis Cell Line:COLO 205 cells Concentration:5-100 μM Incubation Time:24 hours Result:Induced apoptosis in human colorectal carcinoma cells.Western Blot Analysis Cell Line:COLO 205 cells Concentration:5-50 μM Incubation Time:24 hours Result:Degraded 116 kDa PARP into 85 kDa fragments and induced DFF-45 protein degradation and increased the amounts of LC3B I/II proteins than pterostilbene. Markedly decreased phosphorylation of mTOR, p70S6K (Thr389), PI3K, Akt and p38 MAPK in cells.Cell Autophagy Assay Cell Line:COLO 205 cells Concentration:25 and 50 μM Incubation Time:24 hours Result:Showed an inducing effect on autophagy than pterostilbene in COLO 205 cells.

Animal Model:3-4 week old BALB/c nude mice with human colorectal carcinoma COLO 205 tumor xenografts Dosage:10 mg/kg Administration:Intraperitoneal injection; 10 mg/kg once per day for 15 days Result:Significantly inhibited tumor volume and tumor weight after 15 days treatment compared with the pterostilbene-treated mice, and decreased the protein levels of COX-2, MMP-9, VEGF, cyclin D1 and pro-caspase-3 in mice.

3'-HPT

Apoptosis

Apoptosis

Apoptosis

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475231-21-1

272.29

C16H16O4

>98% (HPLC)

DMSO:26 mg/mL (954.83 mM)

COc1cc(/C=C/c(cc2)cc(O)c2O)cc(OC)c1

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(-20℃)

With Ice Pack

≥ 2 years