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6-Methylflavone

CAS No. 29976-75-8

6-Methylflavone( —— )

Catalog No. M21420 CAS No. 29976-75-8

6-Methylflavone is an activator of α1β2γ2L and α1β2 GABAA receptors.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    6-Methylflavone
  • Note
    Research use only, not for human use.
  • Brief Description
    6-Methylflavone is an activator of α1β2γ2L and α1β2 GABAA receptors.
  • Description
    6-Methylflavone is an activator of α1β2γ2L and α1β2 GABAA receptors.
  • In Vitro
    6-Methylflavone is an activator of α1β2γ2L and α1β2 GABAA receptors. 6-Methylflavone enhances the normal response to GABA at recombinant α1β2γ2L and α1β2 GABAA receptors (P<0.0001) at concentrations from 1 to 100 μM. 6-Methylflavone (60 μM) shifts the GABA dose-response curve to the left (n=4, F=16.38, P=0.0004), decreasing the mean EC50 at α1β2γ2L GABAA receptors by 33±5.4%.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    α1β2γ2L GABAA receptor|α1β2 GABAA receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    29976-75-8
  • Formula Weight
    236.27
  • Molecular Formula
    C16H12O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:5 mg/mL (211.62 mM)
  • SMILES
    CC1=CC2=C(C=C1)OC(=CC2=O)C3=CC=CC=C3
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Hall BJ et al. Flumazenil-independent positive modulation of gamma-aminobutyric acid action by 6-methylflavone at human recombinant alpha1beta2gamma2L and alpha1beta2 GABAA receptors. Eur J Pharmacol. 2004 Apr 26;491(1):1-8.
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