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Home - Products - Proteasome/Ubiquitin - Endogenous Metabolite - 5'-Methylthioadenosine

5'-Methylthioadenosine

CAS No. 2457-80-9

5'-Methylthioadenosine( Methylthioadenosine | 5'-(Methylthio)-5'-deoxyadenosine | 5'-Deoxy-5'-(methylthio)adenosine | 5'-S-Methyl-5'-thioadenosine )

Catalog No. M21415 CAS No. 2457-80-9

5'-Methylthioadenosine is produced from S-adenosylmethionine and behaves as a powful inhibitory product.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    5'-Methylthioadenosine
  • Note
    Research use only, not for human use.
  • Brief Description
    5'-Methylthioadenosine is produced from S-adenosylmethionine and behaves as a powful inhibitory product.
  • Description
    5'-Methylthioadenosine is produced from S-adenosylmethionine and behaves as a powful inhibitory product.
  • In Vitro
    Cell Viability Assay Cell Line:MTAP+ and MTAP? NIH3T3 cells, isogenic MTAP+ and MTAP? cell line derived from a human HT1080 fibrosarcoma cell line Concentration:6TG and 2FA in combination with 10 μM MTA Incubation Time:48 hours Result:Significantly increased IC50 concentration in MTAP+ cells, but no significant change in MTAP? cells.
  • In Vivo
    ——
  • Synonyms
    Methylthioadenosine | 5'-(Methylthio)-5'-deoxyadenosine | 5'-Deoxy-5'-(methylthio)adenosine | 5'-S-Methyl-5'-thioadenosine
  • Pathway
    Proteasome/Ubiquitin
  • Target
    Endogenous Metabolite
  • Recptor
    Human Endogenous Metabolite
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2457-80-9
  • Formula Weight
    297.33
  • Molecular Formula
    C11H15N5O3S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:5 mg/mL (168.16 mM);DMF:2.5 mg/mL (8.41 mM);H2O:1 mg/mL (3.36 mM)
  • SMILES
    CSC[C@H]([C@H]([C@H]1O)O)O[C@H]1n1c2ncnc(N)c2nc1
  • Chemical Name
    (2R3R4S5S)-2-(6-amino-9H-purin-9-yl)-5-((methylthio)methyl)tetrahydrofuran-34-diol

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Avila MA et al. Methylthioadenosine. Int J Biochem Cell Biol. 2004 Nov;36(11):2125-30.
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