Diallyl Trisulfide

Research use only, not for human use.

Diallyl Trisulfide is an organic polysulfide compound found in garlic that acts as an H2S donor.

Diallyl Trisulfide is an organic polysulfide compound found in garlic that acts as an H2S donor.

Cell Cytotoxicity Assay Cell Line:A549 Concentration:75 μM, 93.75 μM, 125 μM, 125 μM, 187.5 μM, 250 μM, 375 μM, 500 μM Incubation Time:48 h Result:Was not cytotoxic to A549 cells.Cell Viability Assay Cell Line:A549 Concentration:25 μM, 50 μM, 100 μM Incubation Time: 24 h Result:Significantly inhibited cell activity in a dose-dependent manner. Western Blot Analysis Cell Line:A549 Concentration:25 μM, 50 μM, 100 μM Incubation Time:24 h; 48 h; 72 h Result:Significantly reduced the expression of Bcl-2 protein at a dose of 100 μM for 48 h.significantly increased the expression of Bax protein.RT-PCRCell Line:A549 Concentration:100 μM Incubation Time:48 h Result:Increased the mRNA expression of caspase-3, -8, and -9.Significantly increased the expression of Bax mRNA.Real Time qPCR Cell Line:A549 Concentration:375 μM Incubation Time:24 h, 48 h Result:Increased the expression of antiviral factors RIG-I, IRF-3 and IFN-β.

Animal Model:Kunming mouse model of inflammation induced by naphthaleneDosage:20 mg/kg, 40 mg/kg, 80 mg/kg Administration:Oral gavage (p.o.); Single dose. Before naphthalene treatment (100 mg/kg; p.o., single dose)Result:Inhibited the production of serum nitric oxide (NO) and pulmonary myeloperoxidase (MPO).Significantly reduced the area of inflammatory cell infiltration induced by naphthalene and alleviated lung injury in mice.Animal Model:BABL/c mice model infected with H9N2 AIV Dosage:30 mg/kg Administration:Intraperitoneal injection (i.p.); Once daily for two weeks Result:Reduced the severity of pulmonary edema.Significantly reduced viral load in mouse lungs.

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Others

Other Targets

Others

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2050-87-5

178.3

C6H10S3

>98% (HPLC)

DMSO:5mg/ml(28.04mM)

C=CCSSSCC=C

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(-20℃)

With Ice Pack

≥ 2 years