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TASP0415914
CAS No. 1292300-75-4
TASP0415914( —— )
Catalog No. M21131 CAS No. 1292300-75-4
TASP0415914 is an orally potent inhibitor of phosphoinositide 3-kinase γ (PI3Kγ).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 132 | Get Quote |
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| 5MG | 222 | Get Quote |
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| 10MG | 357 | Get Quote |
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| 25MG | 597 | Get Quote |
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| 50MG | 851 | Get Quote |
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| 100MG | 1152 | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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| 1 mL x 10 mM in DMSO | 129 | In Stock |
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| 5MG | 113 | In Stock |
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| 10MG | 187 | In Stock |
|
| 25MG | 315 | In Stock |
|
| 50MG | 439 | In Stock |
|
| 100MG | 607 | In Stock |
|
| 200MG | 817 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameTASP0415914
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NoteResearch use only, not for human use.
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Brief DescriptionTASP0415914 is an orally potent inhibitor of phosphoinositide 3-kinase γ (PI3Kγ).
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DescriptionTASP0415914 is an orally potent inhibitor of phosphoinositide 3-kinase γ (PI3Kγ).
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In VitroTASP0415914 (compound 8j) shows high metabolic stability in rat/human liver microsomes. TASP0415914 has no CYP inhibition up to 10 μM for CYP1A2, 2C9, 2C19, 2D6 and 3A4.
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In VivoTASP0415914 (compound 8j; 10-100 mg/kg; orally administration; twice daily; for 14 days) treatment suppressed the progression of the disease in a dose-dependent manner in a mouse collagen-induced arthritis (CIA) model. Animal Model:Collagen-primed DBA/1 mice Dosage:10 mg/kg; 30 mg/kg; 100 mg/kg.Administration:Orally administration; twice daily; for 14 daysResult:Suppressed the progression of the disease in a dose-dependent manner.
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Synonyms——
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PathwayPI3K/Akt/mTOR signaling
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TargetPI3K
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RecptorPI3Kγ
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Research Area——
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Indication——
Chemical Information
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CAS Number1292300-75-4
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Formula Weight323.37
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Molecular FormulaC13H17N5O3S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (386.55 mM)
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SMILESCC(=O)Nc1nc(C)c(-c2nc(N3CCCC(O)C3)no2)s1
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Chemical NameN-{5-[3-(3-hydroxypiperidin-1-yl)-124-oxadiazol-5-yl]-4-methyl-13-thiazol-2-yl}acetamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Oka Y Yabuuchi T Oi T et al. Discovery of N-{5-[3-(3-hydroxypiperidin-1-yl)-124-oxadiazol-5-yl]-4-methyl-13-thiazol-2-ylacetamide (TASP0415914) as an orally potent phosphoinositide 3-kinase γ inhibitor for the treatment of inflammatory diseases[J]. Bioorganic & Medicinal Chemistry 2013 21(24):7578-7583.
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