Cart
sales@molnova.com
TASP0415914
CAS No. 1292300-75-4
TASP0415914( —— )
Catalog No. M21131 CAS No. 1292300-75-4
TASP0415914 is an orally potent inhibitor of phosphoinositide 3-kinase γ (PI3Kγ).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 129 | In Stock |
|
| 5MG | 113 | In Stock |
|
| 10MG | 187 | In Stock |
|
| 25MG | 315 | In Stock |
|
| 50MG | 439 | In Stock |
|
| 100MG | 607 | In Stock |
|
| 200MG | 817 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameTASP0415914
-
NoteResearch use only, not for human use.
-
Brief DescriptionTASP0415914 is an orally potent inhibitor of phosphoinositide 3-kinase γ (PI3Kγ).
-
DescriptionTASP0415914 is an orally potent inhibitor of phosphoinositide 3-kinase γ (PI3Kγ).
-
In VitroTASP0415914 (compound 8j) shows high metabolic stability in rat/human liver microsomes. TASP0415914 has no CYP inhibition up to 10 μM for CYP1A2, 2C9, 2C19, 2D6 and 3A4.
-
In VivoTASP0415914 (compound 8j; 10-100 mg/kg; orally administration; twice daily; for 14 days) treatment suppressed the progression of the disease in a dose-dependent manner in a mouse collagen-induced arthritis (CIA) model. Animal Model:Collagen-primed DBA/1 mice Dosage:10 mg/kg; 30 mg/kg; 100 mg/kg.Administration:Orally administration; twice daily; for 14 daysResult:Suppressed the progression of the disease in a dose-dependent manner.
-
Synonyms——
-
PathwayPI3K/Akt/mTOR signaling
-
TargetPI3K
-
RecptorPI3Kγ
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1292300-75-4
-
Formula Weight323.37
-
Molecular FormulaC13H17N5O3S
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 125 mg/mL (386.55 mM)
-
SMILESCC(=O)Nc1nc(C)c(-c2nc(N3CCCC(O)C3)no2)s1
-
Chemical NameN-{5-[3-(3-hydroxypiperidin-1-yl)-124-oxadiazol-5-yl]-4-methyl-13-thiazol-2-yl}acetamide
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Oka Y Yabuuchi T Oi T et al. Discovery of N-{5-[3-(3-hydroxypiperidin-1-yl)-124-oxadiazol-5-yl]-4-methyl-13-thiazol-2-ylacetamide (TASP0415914) as an orally potent phosphoinositide 3-kinase γ inhibitor for the treatment of inflammatory diseases[J]. Bioorganic & Medicinal Chemistry 2013 21(24):7578-7583.
molnova catalog
related products
-
Omipalisib
A highly potent dual inhibitor PI3K/mTOR inhibitor.
-
GS-9901
GS-9901 is a selective, orally active and potent PI3Kδ inhibitor (IC50: 1 nM) for the study of non-Hodgkin's lymphoma and chronic lymphocytic leukemia.
-
mTOR inhibitor 9d
mTOR inhibitor 9d is a dual inhibitor of the protein kinases mTOR and PI3K with an mTOR IC50 value of 0.31 nm, and can be used for the treatment of leukemia, skin cancer, breast cancer, lung cancer and colon cancer.
