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Thioacetazone
CAS No. 104-06-3
Thioacetazone( Diazam | Neotibil | Neustab )
Catalog No. M21119 CAS No. 104-06-3
Thioacetazone is a thiosemicarbazone that thioacetazone treatment of pulmonary tuberculosis.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 50 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | 32 | In Stock |
|
| 500MG | 49 | In Stock |
|
| 1G | 72 | In Stock |
|
Biological Information
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Product NameThioacetazone
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NoteResearch use only, not for human use.
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Brief DescriptionThioacetazone is a thiosemicarbazone that thioacetazone treatment of pulmonary tuberculosis.
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DescriptionThioacetazone is a thiosemicarbazone that thioacetazone treatment of pulmonary tuberculosis.(In Vitro):Thiacetazone is a prodrug that is activated by the mycobacterial monooxygenase EthA, which is also the activator of two other anti-tuberculosis agents, Ethionamide and Isoxyl.(In Vivo):aminobenzaldehydethiosemicarbazone formed/min/mg cytosolic protein, respectively. The ability to metabolize Thiacetazone is the same in the livers of cat, mouse and human, but lagged significantly in that of rat.
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In VitroThiacetazone is a prodrug that is activated by the mycobacterial monooxygenase EthA, which is also the activator of two other anti-tuberculosis agents, Ethionamide and Isoxyl.
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In VivoThe Km and Vmax values for the N-deacetylation of Thiacetazone are 0.57 mM and 0.123 nmol of p-aminobenzaldehydethiosemicarbazone formed/min/mg cytosolic protein, respectively. The ability to metabolize Thiacetazone is the same in the livers of cat, mouse and human, but lagged significantly in that of rat.
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SynonymsDiazam | Neotibil | Neustab
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PathwayOthers
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TargetOther Targets
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Recptorothers
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Research AreaInfection
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IndicationMycobacterium Avium-intracellulare Infection
Chemical Information
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CAS Number104-06-3
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Formula Weight236.29
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Molecular FormulaC10H12N4OS
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (423.21 mM)
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SMILESCC(=O)Nc1ccc(/C=N/NC(N)=S)cc1
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Chemical NameAcetamide N-(4-(((aminothioxomethyl)hydrazono)methyl)phenyl)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.K.A.-T.A.a.G.T.S.: Hong. A controlled comparison of thiacetazone (thioacetazone) plus isoniazid with pas plus isoniazid in Hong Kong[J]. tubercle 1968 49(3):243-280.
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