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Aegeline
CAS No. 456-12-2
Aegeline( —— )
Catalog No. M21098 CAS No. 456-12-2
Aegeline is an alkaloidal-amide isolated from the leaves of Aegle marmelos and have shown antihyperglycemic as well as antidyslipidemic activities in the validated animal models of type 2 diabetes mellitus.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 28 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | 29 | In Stock |
|
Biological Information
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Product NameAegeline
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NoteResearch use only, not for human use.
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Brief DescriptionAegeline is an alkaloidal-amide isolated from the leaves of Aegle marmelos and have shown antihyperglycemic as well as antidyslipidemic activities in the validated animal models of type 2 diabetes mellitus.
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DescriptionAegeline is an alkaloidal-amide isolated from the leaves of Aegle marmelos and have shown antihyperglycemic as well as antidyslipidemic activities in the validated animal models of type 2 diabetes mellitus.
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In VitroAegeline also prevents growth block in cells expressing the more toxic A53T α-synuclein mutant. Restoration of cell growth occurred through inhibition of increased ROS levels, mitochondrial membrane potential loss and nuclear DNA fragmentation, characteristics of apoptosis manifested in α-synuclein or Bax-expressing cells.Aegeline shows weak inhibitory effects on the histamine release from RPMCs, even though still succeed to inhibit when the histamine release induced by thapsigargin.
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research Area——
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Indication——
Chemical Information
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CAS Number456-12-2
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Formula Weight297.3
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Molecular FormulaC18H19NO3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (336.30 mM)
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SMILESCOc1ccc(C(O)CNC(=O)/C=C/c2ccccc2)cc1
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Chemical NameN-[2-hydroxy-2(4-methoxyphenyl) ethyl]-3-phenyl-2-propenamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Aegeline from Aegle marmelos stimulates glucose transport via Akt and Rac1 signaling and contributes to a cytoskeletal rearrangement through PI3K/Rac1[J]. European Journal of Pharmacology 2015 762:419-429.
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