Cart
sales@molnova.com
Home - Products - Others - Other Targets - Aegeline

Aegeline

CAS No. 456-12-2

Aegeline( —— )

Catalog No. M21098 CAS No. 456-12-2

Aegeline is an alkaloidal-amide isolated from the leaves of Aegle marmelos and have shown antihyperglycemic as well as antidyslipidemic activities in the validated animal models of type 2 diabetes mellitus.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
500MG 35 Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    Aegeline
  • Note
    Research use only, not for human use.
  • Brief Description
    Aegeline is an alkaloidal-amide isolated from the leaves of Aegle marmelos and have shown antihyperglycemic as well as antidyslipidemic activities in the validated animal models of type 2 diabetes mellitus.
  • Description
    Aegeline is an alkaloidal-amide isolated from the leaves of Aegle marmelos and have shown antihyperglycemic as well as antidyslipidemic activities in the validated animal models of type 2 diabetes mellitus.
  • In Vitro
    Aegeline also prevents growth block in cells expressing the more toxic A53T α-synuclein mutant. Restoration of cell growth occurred through inhibition of increased ROS levels, mitochondrial membrane potential loss and nuclear DNA fragmentation, characteristics of apoptosis manifested in α-synuclein or Bax-expressing cells.Aegeline shows weak inhibitory effects on the histamine release from RPMCs, even though still succeed to inhibit when the histamine release induced by thapsigargin.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    456-12-2
  • Formula Weight
    297.3
  • Molecular Formula
    C18H19NO3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (336.30 mM)
  • SMILES
    COc1ccc(C(O)CNC(=O)/C=C/c2ccccc2)cc1
  • Chemical Name
    N-[2-hydroxy-2(4-methoxyphenyl) ethyl]-3-phenyl-2-propenamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Aegeline from Aegle marmelos stimulates glucose transport via Akt and Rac1 signaling and contributes to a cytoskeletal rearrangement through PI3K/Rac1[J]. European Journal of Pharmacology 2015 762:419-429.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • (5R)-5-hydroxy-7-(4-...

    Antiviral agent 41 (compound 5) is a diarylheptanoid isolated from Alpinia officinarum. Antiviral agent 41 exhibits potential antiviral activity against influenza virus in vitro.

  • Physalin A

    Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling, it inhibits androgen-independent prostate cancer cell growth through activation of cell apoptosis and downregulation of androgen receptor expression.

  • Eliglustat hemitartr...

    Eliglustat Hemitartrate, with an IC50 of 24 nM, is a specific, potent, oral active glucocerebral glycosidase inhibitor.Eliglustat tartrate shows good potency with an IC50 of 24 nM and specificity against the target enzyme.A novel inhibitor of glucosylceramide synthase (Genz-112638) and assessed its activity in a murine model of Gaucher disease (D409V/null).?Biochemical characterization of Genz-112638 showed good potency (IC(50) approximately 24nM) and specificity against the target enzyme.?

Sign In Join Free