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Home - Products - Proteasome/Ubiquitin - Endogenous Metabolite - Aprocitentan

Aprocitentan

CAS No. 1103522-45-7

Aprocitentan( ACT-132577 )

Catalog No. M21083 CAS No. 1103522-45-7

Aprocitentan is ETA and ETB antagonist .

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 138 In Stock
5MG 112 In Stock
10MG 169 In Stock
25MG 312 In Stock
50MG 431 In Stock
100MG 642 In Stock
200MG 868 In Stock
500MG Get Quote In Stock
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Biological Information

  • Product Name
    Aprocitentan
  • Note
    Research use only, not for human use.
  • Brief Description
    Aprocitentan is ETA and ETB antagonist .
  • Description
    Aprocitentan is ETA and ETB antagonist .(In Vitro):Aprocitentan (ACT-132577) achieves full inhibition of intracellular calcium increase induced by ET-1 on nonrecombinant cells (primary human pulmonary smooth muscle cells and rat aortic smooth muscle cell line A10 and mouse fibroblast cell line 3T3).(In Vivo):Aprocitentan (ACT-132577) has a volume of distribution greater than the plasma volume and a longer half-life than its parent compound in the rat. In rat plasma, the mean recovery of Aprocitentan (ACT-132577) ranges from 82.6% to 90.6%, matrix effect of Aprocitentan (ACT-132577) in rat plasma ranges from 101.4% to 115.2%.
  • In Vitro
    Aprocitentan (ACT-132577) achieves full inhibition of intracellular calcium increase induced by ET-1 on nonrecombinant cells (primary human pulmonary smooth muscle cells and rat aortic smooth muscle cell line A10 and mouse fibroblast cell line 3T3).
  • In Vivo
    Aprocitentan (ACT-132577) has a volume of distribution greater than the plasma volume and a longer half-life than its parent compound in the rat. In rat plasma, the mean recovery of Aprocitentan (ACT-132577) ranges from 82.6% to 90.6%, matrix effect of Aprocitentan (ACT-132577) in rat plasma ranges from 101.4% to 115.2%.
  • Synonyms
    ACT-132577
  • Pathway
    Proteasome/Ubiquitin
  • Target
    Endogenous Metabolite
  • Recptor
    ET-A |ET-B
  • Research Area
    Cardiovascular Disease
  • Indication
    Resistant Hypertension

Chemical Information

  • CAS Number
    1103522-45-7
  • Formula Weight
    546.19
  • Molecular Formula
    C16H14Br2N6O4S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:46 mg/mL (84.22 mM)
  • SMILES
    NS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1
  • Chemical Name
    N-[5-(4-bromophenyl)-6-{2-[(5-bromopyrimidin-2-yl)oxy]ethoxy}pyrimidin-4-yl]sulfuric diamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Trensz F Bortolamiol C Kramberg M et al. Journal of Pharmacology & Experimental Therapeutics 2019.
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