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Tasosartan

CAS No. 145733-36-4

Tasosartan( WAY-ANA 756 )

Catalog No. M21071 CAS No. 145733-36-4

Tasosartan is an antagonist of angiotensin II type 2 (AT2) receptor (IC50 = 1.2 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 126 In Stock
2MG 70 In Stock
5MG 116 In Stock
10MG 187 In Stock
25MG 316 In Stock
50MG 462 In Stock
100MG 644 In Stock
200MG Get Quote In Stock
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Biological Information

  • Product Name
    Tasosartan
  • Note
    Research use only, not for human use.
  • Brief Description
    Tasosartan is an antagonist of angiotensin II type 2 (AT2) receptor (IC50 = 1.2 nM).
  • Description
    Tasosartan is an antagonist of angiotensin II type 2 (AT2) receptor (IC50 = 1.2 nM).
  • In Vitro
    Tasosartan is an orally active nonpeptide AngII antagonist that has demonstrates specific and selective AT1 receptor antagonistic activity in vitro.IC50 for inhibition of specific binding of 125I-AngII to rat adrenal membrane in the absence of proteins in binding buffer is 1.2±0.6 nM.
  • In Vivo
    Administration of Tasosartan at doses of 1.0 and 3.0 mg/kg (iv) significantly (p<0.05) attenuates the pressor response to angiotensin-II in rats.
  • Synonyms
    WAY-ANA 756
  • Pathway
    Endocrinology/Hormones
  • Target
    RAAS
  • Recptor
    AT2 receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    145733-36-4
  • Formula Weight
    411.46
  • Molecular Formula
    C23H21N7O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:125 mg/mL (303.80 mM)
  • SMILES
    Cc1nc(C)c2c(n1)N(Cc1ccc(-c3ccccc3-c3nn[nH]n3)cc1)C(=O)CC2
  • Chemical Name
    8-((2'-(1H-tetrazol-5-yl)-[11'-biphenyl]-4-yl)methyl)-24-dimethyl-58-dihydropyrido[23-d]pyrimidin-7(6H)-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Maillard M P Rossat J Brunner H R et al. Tasosartan enoltasosartan and angiotensin II receptor blockade: The confounding role of protein binding[J]. Journal of Pharmacology & Experimental Therapeutics 2000 295(2):649-654.
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