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Tasosartan

CAS No. 145733-36-4

Tasosartan( WAY-ANA 756 )

Catalog No. M21071 CAS No. 145733-36-4

Tasosartan is an antagonist of angiotensin II type 2 (AT2) receptor (IC50 = 1.2 nM).

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Tasosartan
  • Note
    Research use only, not for human use.
  • Brief Description
    Tasosartan is an antagonist of angiotensin II type 2 (AT2) receptor (IC50 = 1.2 nM).
  • Description
    Tasosartan is an antagonist of angiotensin II type 2 (AT2) receptor (IC50 = 1.2 nM).
  • In Vitro
    Tasosartan is an orally active nonpeptide AngII antagonist that has demonstrates specific and selective AT1 receptor antagonistic activity in vitro.IC50 for inhibition of specific binding of 125I-AngII to rat adrenal membrane in the absence of proteins in binding buffer is 1.2±0.6 nM.
  • In Vivo
    Administration of Tasosartan at doses of 1.0 and 3.0 mg/kg (iv) significantly (p<0.05) attenuates the pressor response to angiotensin-II in rats.
  • Synonyms
    WAY-ANA 756
  • Pathway
    Endocrinology/Hormones
  • Target
    RAAS
  • Recptor
    AT2 receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    145733-36-4
  • Formula Weight
    411.46
  • Molecular Formula
    C23H21N7O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:125 mg/mL (303.80 mM)
  • SMILES
    Cc1nc(C)c2c(n1)N(Cc1ccc(-c3ccccc3-c3nn[nH]n3)cc1)C(=O)CC2
  • Chemical Name
    8-((2'-(1H-tetrazol-5-yl)-[11'-biphenyl]-4-yl)methyl)-24-dimethyl-58-dihydropyrido[23-d]pyrimidin-7(6H)-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Maillard M P Rossat J Brunner H R et al. Tasosartan enoltasosartan and angiotensin II receptor blockade: The confounding role of protein binding[J]. Journal of Pharmacology & Experimental Therapeutics 2000 295(2):649-654.
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