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Aminopterin

CAS No. 54-62-6

Aminopterin( 4-Aminofolic acid | APGA )

Catalog No. M21051 CAS No. 54-62-6

Aminopterin is a synthetic folic acid derivative whose metabolite is a competitive inhibitor of dihydrofolate reductase.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Aminopterin
  • Note
    Research use only, not for human use.
  • Brief Description
    Aminopterin is a synthetic folic acid derivative whose metabolite is a competitive inhibitor of dihydrofolate reductase.
  • Description
    Aminopterin is a synthetic folic acid derivative whose metabolite is a competitive inhibitor of dihydrofolate reductase.(In Vitro):The IC50 value of Aminopterin (4-Aminofolic acid) against CCRF-CEM cells during 72 h of exposure is 4.4 nM.Aminopterin (4-Aminofolic acid) produces a marked inhibition of mitosis in low concentrations in human leukemic leukocytes.
  • In Vitro
    The IC50 value of Aminopterin (4-Aminofolic acid) against CCRF-CEM cells during 72 h of exposure is 4.4 nM.Aminopterin (4-Aminofolic acid) produces a marked inhibition of mitosis in low concentrations in human leukemic leukocytes.
  • In Vivo
    ——
  • Synonyms
    4-Aminofolic acid | APGA
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Antifolate
  • Recptor
    Antifolate
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    54-62-6
  • Formula Weight
    440.41
  • Molecular Formula
    C19H20N8O5
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 14.71 mg/mL (33.40 mM)
  • SMILES
    Nc1nc(N)c2nc(CNc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc3)cnc2n1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Cole P. D . Phase II Trial of Oral Aminopterin for Adults and Children with Refractory Acute Leukemia[J]. Clinical Cancer Research 2005 11(22):8089-8096.
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