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Valorphin
CAS No. 144313-54-2
Valorphin( Valorphin TFAsalt )
Catalog No. M20720 CAS No. 144313-54-2
Valorphin has opioid analgesic activity binds to rat mu-opioid receptor with an IC50 of 14 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 65 | In Stock |
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| 5MG | 93 | In Stock |
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| 10MG | 139 | In Stock |
|
| 25MG | 277 | In Stock |
|
| 50MG | 418 | In Stock |
|
| 100MG | 626 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameValorphin
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NoteResearch use only, not for human use.
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Brief DescriptionValorphin has opioid analgesic activity binds to rat mu-opioid receptor with an IC50 of 14 nM.
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DescriptionValorphin has opioid analgesic activity binds to rat mu-opioid receptor with an IC50 of 14 nM.
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In VitroValorphin is a derivative of dihydrovaltrate with opioid analgesic activity, binds to rat mu-opioid receptor, with an IC50 of 14 nM. Valorphin has low affinity for δ-opioid receptor (IC50, 200 nM) and shows no affinity for κ receptor (IC50, >10 μM). Valorphin (>10 μM) decreases spontaneous firing rate of cerebellar rat Purkinje cells. Valorphin (1 μM) treatment 48 h prior to 0.1 μM epirubicin, or 0.1 μM vincristine, or 0.05 μM vincristine, causes 100% tumor cell death.
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In VivoValorphin exhibits pronounced analgesic activity in mice, rats and rhesus monkeys via s.c, with ED50s of ≤5.2 mg/kg, but barely active after oral administration. Valorphin (1 mg/kg) causes 42% of tumor growth inhibition in female BLRB mice bearing syngeneic mammary carcinoma cells.
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SynonymsValorphin TFAsalt
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PathwayEndocrinology/Hormones
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TargetOpioid Receptor
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RecptorOpioid Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number144313-54-2
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Formula Weight893
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Molecular FormulaC44H60N8O12
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Purity>98% (HPLC)
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Solubility——
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SMILESCC(C)[C@H](N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(N)=O)C(O)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Blishchenko E Y Sazonova O V Kalinina O A et al. Antitumor effect of valorphin in vitro and in vivo: Combined action with cytostatic drugs[J]. Cancer Biology & Therapy 2005 4(1):125-131.
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