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DNQX

CAS No. 2379-57-9

DNQX( FG 9041 )

Catalog No. M20669 CAS No. 2379-57-9

DNQX is a competitive non-NMDA glutamate receptor antagonist (IC50s = 0.5 and 0.1 μM for AMPA and kainate receptors respectively).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    DNQX
  • Note
    Research use only, not for human use.
  • Brief Description
    DNQX is a competitive non-NMDA glutamate receptor antagonist (IC50s = 0.5 and 0.1 μM for AMPA and kainate receptors respectively).
  • Description
    DNQX is a competitive non-NMDA glutamate receptor antagonist (IC50s = 0.5 and 0.1 μM for AMPA and kainate receptors respectively).
  • In Vitro
    DNQX selectively depolarizes thalamic reticular nucleus (TRN) neurons.
  • In Vivo
    DNQX, a specific AMPA receptor antagonist, given as either a 5 mg/kg or 10 mg/kg intraperitoneal dose or into the lateral cerebral ventricle (5 μl of 0.5 mg/ml) significantly diminishes phencyclidine (PCP) (40 mg/kg) and ketamine (80, 100, 120 mg/kg) hsp70 induction in the posterior cingulate and retrosplenial cortex.
  • Synonyms
    FG 9041
  • Pathway
    Neuroscience
  • Target
    GluR
  • Recptor
    AMPA
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2379-57-9
  • Formula Weight
    252.14
  • Molecular Formula
    C8H4N4O6
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:35 mg/mL (138.81 mM)
  • SMILES
    [O-][N+](=O)c1cc2[nH]c(=O)c(=O)[nH]c2cc1[N+]([O-])=O
  • Chemical Name
    67-Dinitroquinoxaline-23(1H4H)-dione

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Muller D Joly M Lynch G . Contributions of quisqualate and NMDA receptors to the induction and expression of LTP[J]. Science 1988 242(4886):1694-1697.
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