Cart
sales@molnova.com
Home - Products - Others - Other Targets - SMS2-IN-2

SMS2-IN-2

CAS No. 2241838-28-6

SMS2-IN-2( SMS2 inhibitors )

Catalog No. M20666 CAS No. 2241838-28-6

SMS2-IN-2 is a potent selective and orally active sphingomyelin synthase 2 (SMS2) inhibitor (IC50s of 100 and 56 μM for SMS2 and SMS1 respectively). SMS2-IN-2 has anti-chronic inflammatory activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 280 In Stock
2MG 161 In Stock
5MG 274 In Stock
10MG 427 In Stock
25MG 702 In Stock
50MG 918 In Stock
100MG 1293 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    SMS2-IN-2
  • Note
    Research use only, not for human use.
  • Brief Description
    SMS2-IN-2 is a potent selective and orally active sphingomyelin synthase 2 (SMS2) inhibitor (IC50s of 100 and 56 μM for SMS2 and SMS1 respectively). SMS2-IN-2 has anti-chronic inflammatory activity.
  • Description
    SMS2-IN-2 is a potent selective and orally active sphingomyelin synthase 2 (SMS2) inhibitor (IC50s of 100 and 56 μM for SMS2 and SMS1 respectively). SMS2-IN-2 has anti-chronic inflammatory activity.
  • In Vitro
    ——
  • In Vivo
    SMS2-IN-2 (Compound 15w; 20, 50 mg/kg/day, p.o. for 6 weeks) reduces chronic inflammation in the db/db mice. Animal Model:Type 2 diabetes mellitus (T2DM) db/db mouse model (four-to-five week)Dosage:20, 50 mg/kg/day Administration:P.O. daily for 6 weeks Result:Significantly reduced IL-6 and insulin levels.
  • Synonyms
    SMS2 inhibitors
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    SMS2
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2241838-28-6
  • Formula Weight
    369.78
  • Molecular Formula
    C19H13ClFN3O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:250 mg/mL (676.08 mM)
  • SMILES
    Fc1ccc(Cl)c(COc2cccc3onc(Nc4cccnc4)c23)c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Mo M Yang J Jiang XCet al.Discovery of 4-Benzyloxybenzo[ d]isoxazole-3-amine Derivatives as Highly Selective and Orally Efficacious Human Sphingomyelin Synthase 2 Inhibitors that Reduce Chronic Inflammation in db/ db Mice[J].J Med Chem. 2018 Sep 27;61(18):8241-8254.?
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • LH-RH, salmon

    Luteinizing Hormone Releasing Hormone (LH-RH) is a pituitary Hormone synthesized in the hypothalamus and plays a crucial role in the control of reproductive function.

  • KPT-6566

    KPT-6566 is a novel selective covalent pin1 inhibitor KPT-6566 shows an IC50 of 640?nM and a Ki of 625.2 nM for PIN1 PPIase domainand has anti-cancer activity.

  • 5(6)-Aminofluorescei...

    5(6)-Aminofluorescein is a high purity and quality chemical used as molecular probe and important as fluorescent agent.

Sign In Join Free