Cart
sales@molnova.com
Home - Products - Cell Cycle/DNA Damage - GPR - NIBR189

NIBR189

CAS No. 1599432-08-2

NIBR189( —— )

Catalog No. M20651 CAS No. 1599432-08-2

NIBR189 is a potent and selective antagonist of EBI2 (GPR183) receptor (IC50 of 11 and 15 nM for human and mouse EBI2 receptors respectively).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 85 In Stock
5MG 76 In Stock
10MG 132 In Stock
25MG 245 In Stock
50MG 423 In Stock
100MG 625 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    NIBR189
  • Note
    Research use only, not for human use.
  • Brief Description
    NIBR189 is a potent and selective antagonist of EBI2 (GPR183) receptor (IC50 of 11 and 15 nM for human and mouse EBI2 receptors respectively).
  • Description
    NIBR189 is a potent and selective antagonist of EBI2 (GPR183) receptor (IC50 of 11 and 15 nM for human and mouse EBI2 receptors respectively).
  • In Vitro
    NIBR189 (0-1 μM; 3 h) blocks migration of U937 cells.NIBR189 (0-10 μM) blocks oxysterol-dependent activation with an IC50 value of 9 nM. Cell Migration Assay Cell Line:U937 cell lines Concentration:0-1 μM Incubation Time:3 hours Result:Blocked the direct migration of U937 cells with an IC50 value of 0.3 nM.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    GPR
  • Recptor
    GPR183
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1599432-08-2
  • Formula Weight
    429.31
  • Molecular Formula
    C21H21BrN2O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:47 mg/mL (109.48 mM)
  • SMILES
    COc1ccc(cc1)C(=O)N1CCN(CC1)C(=O)\C=C\c1ccc(Br)cc1
  • Chemical Name
    (E)-3-(4-bromophenyl)-1-(4-(4-methoxybenzoyl)piperazin-1-yl)prop-2-en-1-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Gessier F Preuss I Yin H et al. Identification and Characterization of Small Molecule Modulators of the Epstein–Barr Virus-Induced Gene 2 (EBI2) Receptor[J]. Journal of Medicinal Chemistry 2014 57(8):3358-3368.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • MK-6892

    MK-6892 is a selective and full agonist for the high-affinity nicotinic acid receptor GPR109A (Ki: 4 nM; GTPγS EC50: 16 nM).MK-6892 evokes a potent internalization of GPR109A in U2OS β-arrestin2-RrGFP cells.MK-6892 shows an EC50 value of 74 nM on calcium mobilization assay.

  • YUM70

    YUM70 is a potent and selective glucose-regulated protein 78 (GRP78) inhibitor(with an IC50 of 1.5 μM for inhibiting GRP78 ATPase activity of the full-length protein).?

  • Myristyl nicotinate

    Myristyl nicotinate is an ester prodrug being developed for delivery of nicotinic acid (NIC) into the skin for prevention of actinic keratosis and its progression to skin cancer.

Sign In Join Free