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NIBR189
CAS No. 1599432-08-2
NIBR189( —— )
Catalog No. M20651 CAS No. 1599432-08-2
NIBR189 is a potent and selective antagonist of EBI2 (GPR183) receptor (IC50 of 11 and 15 nM for human and mouse EBI2 receptors respectively).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 72 | In Stock |
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| 10MG | 125 | In Stock |
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| 25MG | 232 | In Stock |
|
| 50MG | 410 | In Stock |
|
| 100MG | 605 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameNIBR189
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NoteResearch use only, not for human use.
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Brief DescriptionNIBR189 is a potent and selective antagonist of EBI2 (GPR183) receptor (IC50 of 11 and 15 nM for human and mouse EBI2 receptors respectively).
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DescriptionNIBR189 is a potent and selective antagonist of EBI2 (GPR183) receptor (IC50 of 11 and 15 nM for human and mouse EBI2 receptors respectively).
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In VitroNIBR189 (0-1 μM; 3 h) blocks migration of U937 cells.NIBR189 (0-10 μM) blocks oxysterol-dependent activation with an IC50 value of 9 nM. Cell Migration Assay Cell Line:U937 cell lines Concentration:0-1 μM Incubation Time:3 hours Result:Blocked the direct migration of U937 cells with an IC50 value of 0.3 nM.
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In Vivo——
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetGPR
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RecptorGPR183
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Research Area——
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Indication——
Chemical Information
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CAS Number1599432-08-2
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Formula Weight429.31
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Molecular FormulaC21H21BrN2O3
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Purity>98% (HPLC)
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SolubilityDMSO:47 mg/mL (109.48 mM)
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SMILESCOc1ccc(cc1)C(=O)N1CCN(CC1)C(=O)\C=C\c1ccc(Br)cc1
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Chemical Name(E)-3-(4-bromophenyl)-1-(4-(4-methoxybenzoyl)piperazin-1-yl)prop-2-en-1-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Gessier F Preuss I Yin H et al. Identification and Characterization of Small Molecule Modulators of the Epstein–Barr Virus-Induced Gene 2 (EBI2) Receptor[J]. Journal of Medicinal Chemistry 2014 57(8):3358-3368.
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