Phenylbiguanide

Research use only, not for human use.

Phenylbiguanide is a 5-HT3 receptor selective agonist(EC50 : 3.0±0.1 μM).

Phenylbiguanide is a 5-HT3 receptor selective agonist(EC50 : 3.0±0.1 μM).

Phenylbiguanide (1-Phenylbiguanide) is a 5-HT3 receptor selective agonist with pEC50s of 5.57, 4.07, and 4.47 for r5-HT3A(b), h5-HT3A, m5-HT3A(b) , respectively. The effect of Phenylbiguanide (1-Phenylbiguanide hydrochloride) in promoting the growth of the HT29 cell line is investigated. Phenylbiguanide causes a dose dependent proliferation of HT29 cells after 48 hours incubation. The maximum proliferation is at a 5HT concentration of 12.5 μM (P≤0.01). Phenylbiguanide significantly stimulates the growth of cells at concentrations of 3.125 μM (P≤0.05) and 6.25 μM (P≤0.01).

In anaesthetised mice, Phenylbiguanide (PBG), a drug that is known to stimulate cardiopulmonary afferent C-fibres,is injected into the right atrium of the heart and mapped c-Fos expression within specific regions of the central nervous system. Intraatrial injection of PBG produces a reflex cardiorespiratory response including a pronounced bradycardia and a respiratory depression.

N-Phenylbiguanide | PBG | 1-Phenylbiguanide

Endocrinology/Hormones

5-HT Receptor

5-HT3

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102-02-3

177.21

C8H11N5

>98% (HPLC)

DMSO:150 mg/mL (846.45 mM)

NC(=N)NC(=N)Nc1ccccc1

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(-20℃)

With Ice Pack

≥ 2 years