Proxyphylline

Research use only, not for human use.

Proxyphylline is a dual of adenosine A1/A2a receptor inhibitor and phosphodiesterase (PDE) inhibitor. Proxyphylline acts as a cardiac stimulant vasodilator and bronchodilator.

Proxyphylline is a dual of adenosine A1/A2a receptor inhibitor and phosphodiesterase (PDE) inhibitor. Proxyphylline acts as a cardiac stimulant vasodilator and bronchodilator.(In Vitro):Proxyphylline has shown vasodilatory and cardiac stimulatory effects. Proxyphylline produces an increase in the coronary flow associated with a definite positive inotropic effect. Proxyphylline inhibits tracheal PDE-activity and half-maximum relaxation of tracheal smooth muscle is obtained with 100 μg/mL proxyphylline(In Vivo):Proxyphylline exhibits bronchodilatory effect. Proxyphylline inhibits cAMP and cGMP hydrolysis in human lung tissue. The apparent inhibition constant of proxyphylline is 0.06-0.7 mM at low cAMP concentrations and it is 1.0 mM at high cAMP concentrations.

Proxyphylline has shown vasodilatory and cardiac stimulatory effects. Proxyphylline produces an increase in the coronary flow associated with a definite positive inotropic effect. Proxyphylline inhibits tracheal PDE-activity and half-maximum relaxation of tracheal smooth muscle is obtained with 100 μg/mL proxyphylline.

Proxyphylline exhibits bronchodilatory effect. Proxyphylline inhibits cAMP and cGMP hydrolysis in human lung tissue. The apparent inhibition constant of proxyphylline is 0.06-0.7 mM at low cAMP concentrations and it is 1.0 mM at high cAMP concentrations.

7-(2-Hydroxypropyl)theophylline

Endocrinology/Hormones

AChR

adenosine A1/A2a receptor|PDE

Cardiovascular Disease

Cerebral thrombus cerebral insufficiency coronary heart disease

603-00-9

238.24

C10H14N4O3

>98% (HPLC)

DMSO:47 mg/mL (197.28 mM)

CC(O)Cn1cnc2n(C)c(=O)n(C)c(=O)c12

7-(2-hydroxypropyl)-13-dimethyl-37-dihydro-1H-purine-26-dione

(-20℃)

With Ice Pack

≥ 2 years