Sulbutiamine

Research use only, not for human use.

Sulbutiamine is an antioxidant that act by inhibiting oxidative stress induced retinal ganglion cell death.

Sulbutiamine is an antioxidant that act by inhibiting oxidative stress induced retinal ganglion cell death.(In Vitro):Sulbutiamine shows neuroprotective effects on hippocampal CA1 pyramidal neurons subjected to oxygen-glucose deprivation. Sulbutiamine enhances electrophysiological properties such as excitatory synaptic transmissions and intrinsic neuronal membrane input resistance in a concentration-dependent manner. Sulbutiamine attenuates apoptotic cell death induced by serum deprivation and stimulates GSH and GST activity in a dose dependent manner. Furthermore, sulbutiamine decreases the expression of cleaved caspase-3 and AIF.

Sulbutiamine shows neuroprotective effects on hippocampal CA1 pyramidal neurons subjected to oxygen-glucose deprivation. Sulbutiamine enhances electrophysiological properties such as excitatory synaptic transmissions and intrinsic neuronal membrane input resistance in a concentration-dependent manner. Sulbutiamine attenuates apoptotic cell death induced by serum deprivation and stimulates GSH and GST activity in a dose dependent manner. Furthermore, sulbutiamine decreases the expression of cleaved caspase-3 and AIF.

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Bisibuthiamine

Others

Other Targets

Others

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3286-46-2

702.89

C32H46N8O6S2

>98% (HPLC)

DMSO:75 mg/mL (106.70 mM)

CC(C)C(=O)OCC\C(SS\C(CCOC(=O)C(C)C)=C(\C)N(Cc1cnc(C)nc1N)C=O)=C(/C)N(Cc1cnc(C)nc1N)C=O

[(Z)-4-[(4-Amino-2-methylpyrimidin-5-yl)methyl-formylamino]-3-[[(Z)-2-[(4-amino-2-methylpyrimidin-5-yl)methyl-formylamino]-5-(2-methylpropanoyloxy)pent-2-en-3-yl]disulfanyl]pent-3-enyl] 2-methylpropanoate

(-20℃)

With Ice Pack

≥ 2 years