20-DEOXYINGENOL

Research use only, not for human use.

20-DEOXYINGENOL is a natual product.

20-DEOXYINGENOL is a natual product.

20-Deoxyingenol (2.5-10 mM; 24 h) protects chondrocytes against Tert-butyl hydroperoxide solution (TBHP; 100?μM)-induced cell death.20-Deoxyingenol (5-10 mM) decreases the TBHP-induced upregulation of apoptosis protein cleaved-caspase3 and the senescence protein p16INK4a in chondrocytes.20-Deoxyingenol (2.5-40 mM; 24 h) has no cytotoxic effect on chondrocytes at the concentration less than 10?mM.20-Deoxyingenol (10 mM; 24 h) restores autophagy flux in TBHP treated chondrocytes.20-Deoxyingenol (4-10 mM; 24 h) promotes the nuclear level of TFEB in TBHP treated chondrocytes.

20-Deoxyingenol (20 mg/kg/d; i.p. for 8 weeks) alleviates the progression of OA in the DMM model in mice. Animal Model:10-week-old C57BL/6 male wild-type (WT) mice with destabilization of the medial meniscus (DMM)Dosage:20 mg/kg Administration:I.p. one time per day, for eight consecutive weeksResult:Had a slightly wider joint space and reduced bone density and calcification compared with the DMM group.Inhibited the decrease in the thickness of hyaline cartilage (HC), and alleviated the disorder and hypertrophy of chondrocytes in the joint tissues of mice after DMM surgery.Had less erosion on the surface of the articular cartilage and more proteoglycan content.Had more positive staining points of LAMP1 and LC3 II, and less cleaved-caspase3 and P16INK4a.Increased the nuclear level of TFEB.

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Others

Other Targets

Others

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54706-99-9

332.43

C20H28O4

>98% (HPLC)

DMSO:50 mg/mL (150.41 mM)

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(-20℃)

With Ice Pack

≥ 2 years