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zerumbone
CAS No. 471-05-6
zerumbone( —— )
Catalog No. M20446 CAS No. 471-05-6
Zerumbone is a natural monocyclic sesquiterpene first isolated from rhizomes of the wild ginger Z. zerumbet.It has also been shown to have anti-oxidant and anti-inflammatory activities contributing to immunomodulatory and hepatoprotective effects.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 39 | In Stock |
|
| 10MG | 57 | In Stock |
|
| 25MG | 103 | In Stock |
|
| 50MG | 151 | In Stock |
|
| 100MG | 221 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 553 | In Stock |
|
| 1G | 789 | In Stock |
|
Biological Information
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Product Namezerumbone
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NoteResearch use only, not for human use.
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Brief DescriptionZerumbone is a natural monocyclic sesquiterpene first isolated from rhizomes of the wild ginger Z. zerumbet.It has also been shown to have anti-oxidant and anti-inflammatory activities contributing to immunomodulatory and hepatoprotective effects.
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DescriptionZerumbone is a natural monocyclic sesquiterpene first isolated from rhizomes of the wild ginger Z. zerumbet.It has also been shown to have anti-oxidant and anti-inflammatory activities contributing to immunomodulatory and hepatoprotective effects.
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In VitroCell Proliferation Assay Cell Line:HeLa, Coav-3, and MCF-7 Concentration:20.3 μM for HeLa, 24.3 μM for Coav-3, 27.7 μM for MCF-7 Incubation Time:72 h Result:Showed IC50 values of 20.30 ± 1.1, 24.30 ± 0.9 and 27.7 ± 1.2 μM for HeLa, Coav-3, and MCF-7.Apoptosis Analysis Cell Line:HeLa Concentration:20.3 μM Incubation Time:72 h Result:Significantly stimulated caspase-3.Triggered morphological features that relates to apoptosis in a time-dependent manner.
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In VivoAnimal Model:Carrageenan (HY-125474)-induced mice paw edema/Cotton pellet-induced granuloma mice Dosage:5 mg/kg, 10 mg/kg, 50 mg/kg, 100 mg/kg Administration:Intraperitoneal injection (i.p.)Result: Significantly produced dose-dependent inhibition of paw oedema induced by carrageenan in mice with inhibition of 33.3, 66.7, 83.3, and 83.3%, respectively.Produced a significant reduction on the granulomatous tissue formation on implanted cotton pellets with inhibition of 34.8, 60.6 and 70.6%, respectively.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research Area——
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Indication——
Chemical Information
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CAS Number471-05-6
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Formula Weight218.33
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Molecular FormulaC15H22O
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Purity>98% (HPLC)
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SolubilityDMSO:44 mg/mL (201.53 mM)
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SMILESC\C1=C/CC(C)(C)\C=C\C(=O)\C(C)=C\CC1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Ho Y C Lee S S Yang M L et al. Zerumbone reduced the inflammatory response of acute lung injury in endotoxin-treated mice via Akt-NFκB pathway[J]. Chemico-biological interactions 2017 271:9.
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