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Paederosidic acid
CAS No. 18842-98-3
Paederosidic acid( —— )
Catalog No. M20407 CAS No. 18842-98-3
Paederosidic acid has significant anti-tumor anticonvulsant and sedative effects. Paederosidic acid increases brain gamma-aminobutyric acid and decreases glutamic acid in the brain and it up-regulates expressions of GAD 65 may be a promising future therapeutic agent for treatment of epilepsy.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 10MG | 117 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NamePaederosidic acid
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NoteResearch use only, not for human use.
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Brief DescriptionPaederosidic acid has significant anti-tumor anticonvulsant and sedative effects. Paederosidic acid increases brain gamma-aminobutyric acid and decreases glutamic acid in the brain and it up-regulates expressions of GAD 65 may be a promising future therapeutic agent for treatment of epilepsy.
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DescriptionPaederosidic acid has significant anti-tumor anticonvulsant and sedative effects. Paederosidic acid increases brain gamma-aminobutyric acid and decreases glutamic acid in the brain and it up-regulates expressions of GAD 65 may be a promising future therapeutic agent for treatment of epilepsy.
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In VitroPaederosidic acid (40 μg/ml; 24 hours and 48 hours) has no significant effect on BSAS-2B cells, it exhibits obvious effects on NCI-H1650, HCC827, A549 cells with IC50 values of40.68, 42.58, and 36.48 μg/ml, respectively.Paederosidic acid induces mitochondria-mediated apoptosis via up-regulation of caspase-3, caspase-8, caspase-9, Bid, Bax, down-regulation ofBcl-2 and stimulating the release of Cyto-C from mitochondria in lung cancer cells..
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In Vivo——
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Synonyms——
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PathwayAngiogenesis
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TargetBcl-2
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RecptorBcl-2
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Research Area——
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Indication——
Chemical Information
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CAS Number18842-98-3
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Formula Weight464.4
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Molecular FormulaC18H24O12S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (215.31 mM)
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SMILES[H][C@]12[C@@H](O)C=C(COC(=O)SC)[C@@]1([H])[C@H](O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)OC=C2C(O)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Yu P Shi L Song M et al. Antitumor activity of paederosidic acid in human non-small cell lung cancer cells via inducing mitochondria-mediated apoptosis[J]. Chemico-Biological Interactions 2017 269:33-40.
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