Chelidonic acid

Research use only, not for human use.

Chelidonic acid is a component of Chelidonium majus L. used as a mild analgesic an antimicrobial an acentral nervous system sedative. Chelidonic acid also shows anti-inflammatory activity.

Chelidonic acid is a component of Chelidonium majus L. used as a mild analgesic an antimicrobial an acentral nervous system sedative. Chelidonic acid also shows anti-inflammatory activity.

Chelidonic acid dose-dependently decreases IL-6 production at 0.1-10 μM, inhibits expression of IL-6 mRNA at 1-10 μM.Chelidonic acid (0.1-10 μM) decreases caspase-1 activation, nuclear NF-κB activation, and increases cytosol NF-κB activation.Chelidonic acid is a glutamate decarboxylase inhibitor, with a Ki of 1.2 μM. Chelidonic acid does not promote formation of apoenzyme or react with free pyridoxal-P.

Chelidonic acid (0.2, 2 mg/kg p.o.) attenuates allergic reaction induced by ovalbumin in mice.

Jerva acid | Jervaic acid | γ-Pyrone-26-dicarboxylic acid

Apoptosis

Caspase

Caspase-1|NF-κB

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99-32-1

184.1

C7H4O6

>98% (HPLC)

DMSO:4 mg/mL (21.72 mM)

OC(=O)c1cc(=O)cc(o1)C(O)=O

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(-20℃)

With Ice Pack

≥ 2 years