Methyl nicotinate

Research use only, not for human use.

Methyl nicotinate is the methyl ester of that is used as an active ingredient as a rubefacient in over-the-counter topical preparations indicated for muscle and joint pain. The action of methyl nicotinate as a rubefacient is thought to involve peripheral vasodilation.

Methyl nicotinate is the methyl ester of that is used as an active ingredient as a rubefacient in over-the-counter topical preparations indicated for muscle and joint pain. The action of methyl nicotinate as a rubefacient is thought to involve peripheral vasodilation.

Cell Cytotoxicity Assay Cell Line:HDFn (Human neonatal fibroblast cell line) Concentration:1 mg/mL, .2.5 mg/L, 5 mg/L, 7.5 mg/L and 10 mg/mL Incubation Time:24 h Result:Was extremely toxic to fibroblasts at 10mg/mL concentration, and 90% of the cells were still alive at5 mg/mL concentration.

Animal Model:Writhing model of Swiss albino mice induced by acetic acidDosage:5 mg/kg, 10 mg/kg Administration:Oral gavage; Single dose. Before Acetic acid treatment (10 mg/kg; i.p.; Single dose)Result:Caused a significant reduction in the number of writhes induced by acetic acid.At dose of 10 mg/kg, has a similar analgesic effect to Aspirin (HY-14654) within 30 minutes.Animal Model: Hot plate test Swiss albino mouse model Dosage:5 mg/kg, 10 mg/kg Administration:Oral gavage; Single dose Result:Could significantly prolong the latency of mice's response to thermal pain after 30 minutes of administration.Animal Model: Chorioallantoic Membrane (CAM) model Dosage:5 mg/mL/egg, 1 mg/mL/egg, 100 mg/mL/egg Administration:Result:Promoted microvasodilation at 5 mg/mL/egg.Promoted vasodilation to a greater extent, but mild bleeding occurred at 10 mg/mL/egg. Caused extreme vasodilation, leading to blood vessel rupture and bleeding at 100 mg/mL/egg.

methyl pyridine-3-carboxylate

Others

Other Targets

Others

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93-60-7

137.14

C7H7NO2

>98% (HPLC)

DMSO:27 mg/mL (196.87 mM)

COC(=O)c1cccnc1

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(-20℃)

With Ice Pack

≥ 2 years